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Completeness of RET testing in patients with medullary thyroid carcinoma in Denmark 1997–2013: a nationwide study
BACKGROUND: The completeness of REarranged during Transfection (RET) testing in patients with medullary thyroid carcinoma (MTC) was recently reported as 60%. However, the completeness on a population level is unknown. Similarly, it is unknown if the first Danish guidelines from 2002, recommending RE...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330966/ https://www.ncbi.nlm.nih.gov/pubmed/30666164 http://dx.doi.org/10.2147/CLEP.S183268 |
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author | Mathiesen, Jes Sloth Kroustrup, Jens Peter Vestergaard, Peter Stochholm, Kirstine Poulsen, Per Løgstrup Rasmussen, Åse Krogh Feldt-Rasmussen, Ulla Schytte, Sten Londero, Stefano Christian Pedersen, Henrik Baymler Hahn, Christoffer Holst Bentzen, Jens Möller, Sören Gaustadnes, Mette Rossing, Maria Nielsen, Finn Cilius Brixen, Kim Frederiksen, Anja Lisbeth Godballe, Christian |
author_facet | Mathiesen, Jes Sloth Kroustrup, Jens Peter Vestergaard, Peter Stochholm, Kirstine Poulsen, Per Løgstrup Rasmussen, Åse Krogh Feldt-Rasmussen, Ulla Schytte, Sten Londero, Stefano Christian Pedersen, Henrik Baymler Hahn, Christoffer Holst Bentzen, Jens Möller, Sören Gaustadnes, Mette Rossing, Maria Nielsen, Finn Cilius Brixen, Kim Frederiksen, Anja Lisbeth Godballe, Christian |
author_sort | Mathiesen, Jes Sloth |
collection | PubMed |
description | BACKGROUND: The completeness of REarranged during Transfection (RET) testing in patients with medullary thyroid carcinoma (MTC) was recently reported as 60%. However, the completeness on a population level is unknown. Similarly, it is unknown if the first Danish guidelines from 2002, recommending RET testing in all MTC patients, improved completeness in Denmark. We conducted a nationwide retrospective cohort study aiming to evaluate the completeness of RET testing in the Danish MTC cohort. Additionally, we aimed to assess the completeness before and after publication of the first Danish guidelines and characterize MTC patients who had not been tested. METHODS: The study included 200 patients identified from the nationwide Danish MTC cohort 1997–2013. To identify RET tested MTC patients before December 31, 2014, the MTC cohort was cross-checked with the nationwide Danish RET cohort 1994–2014. To characterize MTC patients who had not been RET tested, we reviewed their medical records and compared them with MTC patients who had been tested. RESULTS: Completeness of RET testing in the overall MTC cohort was 87% (95% CI: 0.81–0.91; 173/200). In the adjusted MTC cohort, after excluding patients diagnosed with hereditary MTC by screening, completeness was 83% (95% CI: 0.76–0.88; 131/158). Completeness was 88% (95% CI: 0.75–0.95; 42/48) and 81% (95% CI: 0.72–0.88) (89/110) before and after publication of the first Danish guidelines, respectively. Patients not RET tested had a higher median age at diagnosis compared to those RET tested. Median time to death was shorter in those not tested relative to those tested. CONCLUSION: The completeness of RET testing in MTC patients in Denmark seems to be higher than reported in other cohorts. No improvement in completeness was detected after publication of the first Danish guidelines. In addition, data indicate that advanced age and low life expectancy at MTC diagnosis may serve as prognostic indicators to identify patients having a higher likelihood of missing the compulsory RET test. |
format | Online Article Text |
id | pubmed-6330966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-63309662019-01-21 Completeness of RET testing in patients with medullary thyroid carcinoma in Denmark 1997–2013: a nationwide study Mathiesen, Jes Sloth Kroustrup, Jens Peter Vestergaard, Peter Stochholm, Kirstine Poulsen, Per Løgstrup Rasmussen, Åse Krogh Feldt-Rasmussen, Ulla Schytte, Sten Londero, Stefano Christian Pedersen, Henrik Baymler Hahn, Christoffer Holst Bentzen, Jens Möller, Sören Gaustadnes, Mette Rossing, Maria Nielsen, Finn Cilius Brixen, Kim Frederiksen, Anja Lisbeth Godballe, Christian Clin Epidemiol Original Research BACKGROUND: The completeness of REarranged during Transfection (RET) testing in patients with medullary thyroid carcinoma (MTC) was recently reported as 60%. However, the completeness on a population level is unknown. Similarly, it is unknown if the first Danish guidelines from 2002, recommending RET testing in all MTC patients, improved completeness in Denmark. We conducted a nationwide retrospective cohort study aiming to evaluate the completeness of RET testing in the Danish MTC cohort. Additionally, we aimed to assess the completeness before and after publication of the first Danish guidelines and characterize MTC patients who had not been tested. METHODS: The study included 200 patients identified from the nationwide Danish MTC cohort 1997–2013. To identify RET tested MTC patients before December 31, 2014, the MTC cohort was cross-checked with the nationwide Danish RET cohort 1994–2014. To characterize MTC patients who had not been RET tested, we reviewed their medical records and compared them with MTC patients who had been tested. RESULTS: Completeness of RET testing in the overall MTC cohort was 87% (95% CI: 0.81–0.91; 173/200). In the adjusted MTC cohort, after excluding patients diagnosed with hereditary MTC by screening, completeness was 83% (95% CI: 0.76–0.88; 131/158). Completeness was 88% (95% CI: 0.75–0.95; 42/48) and 81% (95% CI: 0.72–0.88) (89/110) before and after publication of the first Danish guidelines, respectively. Patients not RET tested had a higher median age at diagnosis compared to those RET tested. Median time to death was shorter in those not tested relative to those tested. CONCLUSION: The completeness of RET testing in MTC patients in Denmark seems to be higher than reported in other cohorts. No improvement in completeness was detected after publication of the first Danish guidelines. In addition, data indicate that advanced age and low life expectancy at MTC diagnosis may serve as prognostic indicators to identify patients having a higher likelihood of missing the compulsory RET test. Dove Medical Press 2019-01-10 /pmc/articles/PMC6330966/ /pubmed/30666164 http://dx.doi.org/10.2147/CLEP.S183268 Text en © 2019 Mathiesen et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Mathiesen, Jes Sloth Kroustrup, Jens Peter Vestergaard, Peter Stochholm, Kirstine Poulsen, Per Løgstrup Rasmussen, Åse Krogh Feldt-Rasmussen, Ulla Schytte, Sten Londero, Stefano Christian Pedersen, Henrik Baymler Hahn, Christoffer Holst Bentzen, Jens Möller, Sören Gaustadnes, Mette Rossing, Maria Nielsen, Finn Cilius Brixen, Kim Frederiksen, Anja Lisbeth Godballe, Christian Completeness of RET testing in patients with medullary thyroid carcinoma in Denmark 1997–2013: a nationwide study |
title | Completeness of RET testing in patients with medullary thyroid carcinoma in Denmark 1997–2013: a nationwide study |
title_full | Completeness of RET testing in patients with medullary thyroid carcinoma in Denmark 1997–2013: a nationwide study |
title_fullStr | Completeness of RET testing in patients with medullary thyroid carcinoma in Denmark 1997–2013: a nationwide study |
title_full_unstemmed | Completeness of RET testing in patients with medullary thyroid carcinoma in Denmark 1997–2013: a nationwide study |
title_short | Completeness of RET testing in patients with medullary thyroid carcinoma in Denmark 1997–2013: a nationwide study |
title_sort | completeness of ret testing in patients with medullary thyroid carcinoma in denmark 1997–2013: a nationwide study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330966/ https://www.ncbi.nlm.nih.gov/pubmed/30666164 http://dx.doi.org/10.2147/CLEP.S183268 |
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