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Drug resistance profiles and trends in drug-resistant tuberculosis at a major hospital in Guizhou Province of China

OBJECTIVES: Tuberculosis (TB) is the leading cause of death from infectious diseases in the world, with an estimated 1.6 million deaths from TB in 2017. The objectives of this study were to determine drug resistance profiles of Mycobacterium tuberculosis clinical isolates and to analyze the trends i...

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Autores principales: Lan, Yuanbo, Li, Yuqin, Chen, Ling, Zhang, Jianyong, Zhang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330984/
https://www.ncbi.nlm.nih.gov/pubmed/30666136
http://dx.doi.org/10.2147/IDR.S188538
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author Lan, Yuanbo
Li, Yuqin
Chen, Ling
Zhang, Jianyong
Zhang, Hong
author_facet Lan, Yuanbo
Li, Yuqin
Chen, Ling
Zhang, Jianyong
Zhang, Hong
author_sort Lan, Yuanbo
collection PubMed
description OBJECTIVES: Tuberculosis (TB) is the leading cause of death from infectious diseases in the world, with an estimated 1.6 million deaths from TB in 2017. The objectives of this study were to determine drug resistance profiles of Mycobacterium tuberculosis clinical isolates and to analyze the trends in drug-resistant and multidrug-resistant tuberculosis (MDR-TB) from 2008 to 2015 at a major hospital in Guizhou, a high-TB burden and resource-limited province of China. PATIENTS AND METHODS: A total of 462 clinical isolates were collected from patients with pulmonary TB during the period from January 2013 to December 2015 and used for determining drug resistance profiles against four first-line and six second-line anti-TB drugs, and the results were compared with those of two previous studies. RESULTS: Exactly 4.4% of new and 44.1% of previously treated TB cases were MDR/rifampicin-resistant TB (RR-TB), which were higher than the 2017 global average numbers of 3.5% and 18%, respectively. There were many drug-resistant patterns among MDR-TB isolates and most of them were resistant to three or four anti-TB drugs. The trends in drug-resistant and MDR-TB declined at the hospital from 2008 to 2015. CONCLUSION: Results of this study show that the prevalence of MDR/RR-TB at a major hospital in Guizhou is higher than the global average and confirm the existence of heterogeneity in drug resistance patterns of MDR-TB isolates. Additionally, three practical measures have played an important role in the overall decline of MDR-TB at the hospital from 2008 to 2015.
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spelling pubmed-63309842019-01-21 Drug resistance profiles and trends in drug-resistant tuberculosis at a major hospital in Guizhou Province of China Lan, Yuanbo Li, Yuqin Chen, Ling Zhang, Jianyong Zhang, Hong Infect Drug Resist Original Research OBJECTIVES: Tuberculosis (TB) is the leading cause of death from infectious diseases in the world, with an estimated 1.6 million deaths from TB in 2017. The objectives of this study were to determine drug resistance profiles of Mycobacterium tuberculosis clinical isolates and to analyze the trends in drug-resistant and multidrug-resistant tuberculosis (MDR-TB) from 2008 to 2015 at a major hospital in Guizhou, a high-TB burden and resource-limited province of China. PATIENTS AND METHODS: A total of 462 clinical isolates were collected from patients with pulmonary TB during the period from January 2013 to December 2015 and used for determining drug resistance profiles against four first-line and six second-line anti-TB drugs, and the results were compared with those of two previous studies. RESULTS: Exactly 4.4% of new and 44.1% of previously treated TB cases were MDR/rifampicin-resistant TB (RR-TB), which were higher than the 2017 global average numbers of 3.5% and 18%, respectively. There were many drug-resistant patterns among MDR-TB isolates and most of them were resistant to three or four anti-TB drugs. The trends in drug-resistant and MDR-TB declined at the hospital from 2008 to 2015. CONCLUSION: Results of this study show that the prevalence of MDR/RR-TB at a major hospital in Guizhou is higher than the global average and confirm the existence of heterogeneity in drug resistance patterns of MDR-TB isolates. Additionally, three practical measures have played an important role in the overall decline of MDR-TB at the hospital from 2008 to 2015. Dove Medical Press 2019-01-10 /pmc/articles/PMC6330984/ /pubmed/30666136 http://dx.doi.org/10.2147/IDR.S188538 Text en © 2019 Lan et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Lan, Yuanbo
Li, Yuqin
Chen, Ling
Zhang, Jianyong
Zhang, Hong
Drug resistance profiles and trends in drug-resistant tuberculosis at a major hospital in Guizhou Province of China
title Drug resistance profiles and trends in drug-resistant tuberculosis at a major hospital in Guizhou Province of China
title_full Drug resistance profiles and trends in drug-resistant tuberculosis at a major hospital in Guizhou Province of China
title_fullStr Drug resistance profiles and trends in drug-resistant tuberculosis at a major hospital in Guizhou Province of China
title_full_unstemmed Drug resistance profiles and trends in drug-resistant tuberculosis at a major hospital in Guizhou Province of China
title_short Drug resistance profiles and trends in drug-resistant tuberculosis at a major hospital in Guizhou Province of China
title_sort drug resistance profiles and trends in drug-resistant tuberculosis at a major hospital in guizhou province of china
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330984/
https://www.ncbi.nlm.nih.gov/pubmed/30666136
http://dx.doi.org/10.2147/IDR.S188538
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