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High prevalence of secondary bladder cancer in men on radiotherapy for prostate cancer: evidence from a meta-analysis
OBJECTIVE: To assess whether radiotherapy (RT) for prostate cancer (PCa) was a risk factor for secondary bladder cancer (BLCa) through a meta-analysis. MATERIALS AND METHODS: The MEDLINE, Embase, and the Cochrane Library were systematically searched for all studies investigating the risk of BLCa in...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331076/ https://www.ncbi.nlm.nih.gov/pubmed/30666156 http://dx.doi.org/10.2147/CMAR.S185867 |
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author | Zhao, Shankun Xie, Qiang Yang, Redian Wang, Jiamin Zhang, Chaofeng Luo, Lianmin Zhu, Zhiguo Liu, Yangzhou Li, Ermao Zhao, Zhigang |
author_facet | Zhao, Shankun Xie, Qiang Yang, Redian Wang, Jiamin Zhang, Chaofeng Luo, Lianmin Zhu, Zhiguo Liu, Yangzhou Li, Ermao Zhao, Zhigang |
author_sort | Zhao, Shankun |
collection | PubMed |
description | OBJECTIVE: To assess whether radiotherapy (RT) for prostate cancer (PCa) was a risk factor for secondary bladder cancer (BLCa) through a meta-analysis. MATERIALS AND METHODS: The MEDLINE, Embase, and the Cochrane Library were systematically searched for all studies investigating the risk of BLCa in patients with RT. The association between RT and risk of BLCa was summarized using hazard ratio with a 95%CI. The protocol for this meta-analysis is available from PROSPERO (CRD42018090075). RESULTS: Overall, 619,479 participants (age: 57–79 years) were included from 15 studies, 206,852 of whom were patients who received RT. Synthesis of results indicated that RT was significantly associated with an increased risk of BLCa compared with the risk in those who received radical prostatectomy or non-RT (overall HR=1.6, 95%CI: 1.33–1.92, P<0.001). The results were consistent when restricted to a 5-year lag period (HR=1.84, 95%CI: 1.26–2.69, P=0.002) and multivariable adjustment (HR=1.96, 95%CI: 1.47–2.62, P<0.001), but not for 10-year lag period (HR=1.93, 95%CI: 0.9– 4.16, P=0.093) and brachytherapy subgroup (HR=1.33, 95%CI: 0.87–2.05, P=0.188). The GRADE-profiler revealed that the rate of events of BLCa on average in the RT-patients and the non-RT control was 2,462/183,669 (1.3%) and 4,263/382,761(1.1%), respectively; the overall quality of the evidence was low. CONCLUSION: Patients who received RT for PCa was associated with higher risks of developing secondary BLCa compared to those unexposed to RT, but the absolute effect was low. |
format | Online Article Text |
id | pubmed-6331076 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-63310762019-01-21 High prevalence of secondary bladder cancer in men on radiotherapy for prostate cancer: evidence from a meta-analysis Zhao, Shankun Xie, Qiang Yang, Redian Wang, Jiamin Zhang, Chaofeng Luo, Lianmin Zhu, Zhiguo Liu, Yangzhou Li, Ermao Zhao, Zhigang Cancer Manag Res Review OBJECTIVE: To assess whether radiotherapy (RT) for prostate cancer (PCa) was a risk factor for secondary bladder cancer (BLCa) through a meta-analysis. MATERIALS AND METHODS: The MEDLINE, Embase, and the Cochrane Library were systematically searched for all studies investigating the risk of BLCa in patients with RT. The association between RT and risk of BLCa was summarized using hazard ratio with a 95%CI. The protocol for this meta-analysis is available from PROSPERO (CRD42018090075). RESULTS: Overall, 619,479 participants (age: 57–79 years) were included from 15 studies, 206,852 of whom were patients who received RT. Synthesis of results indicated that RT was significantly associated with an increased risk of BLCa compared with the risk in those who received radical prostatectomy or non-RT (overall HR=1.6, 95%CI: 1.33–1.92, P<0.001). The results were consistent when restricted to a 5-year lag period (HR=1.84, 95%CI: 1.26–2.69, P=0.002) and multivariable adjustment (HR=1.96, 95%CI: 1.47–2.62, P<0.001), but not for 10-year lag period (HR=1.93, 95%CI: 0.9– 4.16, P=0.093) and brachytherapy subgroup (HR=1.33, 95%CI: 0.87–2.05, P=0.188). The GRADE-profiler revealed that the rate of events of BLCa on average in the RT-patients and the non-RT control was 2,462/183,669 (1.3%) and 4,263/382,761(1.1%), respectively; the overall quality of the evidence was low. CONCLUSION: Patients who received RT for PCa was associated with higher risks of developing secondary BLCa compared to those unexposed to RT, but the absolute effect was low. Dove Medical Press 2019-01-10 /pmc/articles/PMC6331076/ /pubmed/30666156 http://dx.doi.org/10.2147/CMAR.S185867 Text en © 2019 Zhao et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Zhao, Shankun Xie, Qiang Yang, Redian Wang, Jiamin Zhang, Chaofeng Luo, Lianmin Zhu, Zhiguo Liu, Yangzhou Li, Ermao Zhao, Zhigang High prevalence of secondary bladder cancer in men on radiotherapy for prostate cancer: evidence from a meta-analysis |
title | High prevalence of secondary bladder cancer in men on radiotherapy for prostate cancer: evidence from a meta-analysis |
title_full | High prevalence of secondary bladder cancer in men on radiotherapy for prostate cancer: evidence from a meta-analysis |
title_fullStr | High prevalence of secondary bladder cancer in men on radiotherapy for prostate cancer: evidence from a meta-analysis |
title_full_unstemmed | High prevalence of secondary bladder cancer in men on radiotherapy for prostate cancer: evidence from a meta-analysis |
title_short | High prevalence of secondary bladder cancer in men on radiotherapy for prostate cancer: evidence from a meta-analysis |
title_sort | high prevalence of secondary bladder cancer in men on radiotherapy for prostate cancer: evidence from a meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331076/ https://www.ncbi.nlm.nih.gov/pubmed/30666156 http://dx.doi.org/10.2147/CMAR.S185867 |
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