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Topical treatment with gallium maltolate reduces Treponema pallidum subsp. pertenue burden in primary experimental lesions in a rabbit model of yaws

BACKGROUND: Gallium is a semi-metallic element known since the 1930s to have antimicrobial activity. This activity stems primarily from gallium's ability to mimic trivalent iron and disrupt specific Fe(III)-dependent pathways, particularly DNA synthesis (due to inhibition of ribonucleotide redu...

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Detalles Bibliográficos
Autores principales:	Giacani, Lorenzo, Bernstein, Lawrence R., Haynes, Austin M., Godornes, B. Charmie, Ciccarese, Giulia, Drago, Francesco, Parodi, Aurora, Valdevit, Sefora, Anselmi, Luca, Tomasini, Carlo Francesco, Baca, Arthur M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331133/ https://www.ncbi.nlm.nih.gov/pubmed/30601824 http://dx.doi.org/10.1371/journal.pntd.0007076

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