Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization

[Image: see text] Covalent labeling of G protein-coupled receptors (GPCRs) by small molecules is a powerful approach to understand binding modes, mechanism of action, pharmacology, and even facilitate structure elucidation. We report the first covalent positive allosteric modulator (PAM) for a class...

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Detalles Bibliográficos
Autores principales: Doornbos, Maarten L. J., Wang, Xuesong, Vermond, Sophie C., Peeters, Luc, Pérez-Benito, Laura, Trabanco, Andrés A., Lavreysen, Hilde, Cid, José María, Heitman, Laura H., Tresadern, Gary, IJzerman, Adriaan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331142/
https://www.ncbi.nlm.nih.gov/pubmed/29494768
http://dx.doi.org/10.1021/acs.jmedchem.8b00051

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