Cargando…

Synthesis, Biological Evaluation and Structure–Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors

[Image: see text] A series of derivatives of the potent dual soluble epoxide hydrolase (sEH)/5-lipoxygenase-activating protein (FLAP) inhibitor diflapolin was designed, synthesized, and characterized by (1)H NMR, (13)C NMR, and elemental analysis. These novel compounds were biologically evaluated fo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vieider, Lisa, Romp, Erik, Temml, Veronika, Fischer, Jana, Kretzer, Christian, Schoenthaler, Martin, Taha, Abdulla, Hernández-Olmos, Victor, Sturm, Sonja, Schuster, Daniela, Werz, Oliver, Garscha, Ulrike, Matuszczak, Barbara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331193/ https://www.ncbi.nlm.nih.gov/pubmed/30655948 http://dx.doi.org/10.1021/acsmedchemlett.8b00415

Ejemplares similares

Synthesis and structure–activity relationships for some novel diflapolin derivatives with benzimidazole subunit
por: Vieider, Lisa, et al.
Publicado: (2022)

Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase
por: Garscha, Ulrike, et al.
Publicado: (2017)

Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening
por: Temml, Veronika, et al.
Publicado: (2017)

Benzoxazolone-5-Urea Derivatives as Human Soluble Epoxide Hydrolase (sEH) Inhibitors
por: Gur Maz, Tugce, et al.
Publicado: (2023)

Association of the sEH gene promoter polymorphisms and haplotypes with preeclampsia
por: Sarı, İsmail, et al.
Publicado: (2020)

Activity of sEH and Oxidant Status during Systemic Bovine Coliform Mastitis
por: Mavangira, Vengai, et al.
Publicado: (2021)

Differential Effects of sEH Inhibitors on the Proliferation and Migration of Vascular Smooth Muscle Cells
por: Kim, Hyo Seon, et al.
Publicado: (2017)

Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation
por: Dileepan, Mythili, et al.
Publicado: (2019)

Repositioning of Quinazolinedione-Based Compounds on Soluble Epoxide Hydrolase (sEH) through 3D Structure-Based Pharmacophore Model-Driven Investigation
por: Gazzillo, Erica, et al.
Publicado: (2022)

Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: In Vitro and In Vivo Anti-Inflammatory Characterization
por: Cerqua, Ida, et al.
Publicado: (2022)

In Vitro and In Silico Insights into sEH Inhibitors with Amide-Scaffold from the Leaves of Capsicum chinense Jacq.
por: Kim, Jang Hoon, et al.
Publicado: (2018)

sEH Inhibitor Tppu Ameliorates Cecal Ligation and Puncture-Induced Sepsis by Regulating Macrophage Functions
por: Chen, Zhihui, et al.
Publicado: (2020)

Dual sEH/COX-2 Inhibition Using PTUPB—A Promising Approach to Antiangiogenesis-Induced Nephrotoxicity
por: Jankiewicz, Wojciech K., et al.
Publicado: (2021)

COX-2/sEH Dual Inhibitor PTUPB Alleviates CCl(4)-Induced Liver Fibrosis and Portal Hypertension
por: Zhao, Zhifeng, et al.
Publicado: (2021)

Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury
por: Zhang, Juan, et al.
Publicado: (2023)

Kampagne „ICH SEH, ICH SEH“ macht auf Diabetes aufmerksam
Publicado: (2020)

Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library
por: Litovchick, Alexander, et al.
Publicado: (2015)

Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury
por: Zhang, Juan, et al.
Publicado: (2023)

Development of an online SPE–LC–MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors
por: Schebb, Nils Helge, et al.
Publicado: (2011)

sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury
por: Bergmann, Christian B., et al.
Publicado: (2022)

COX-2/sEH dual inhibitor PTUPB suppresses glioblastoma growth by targeting epidermal growth factor receptor and hyaluronan mediated motility receptor
por: Li, Junyang, et al.
Publicado: (2017)

A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation
por: Yang, Hui-Hui, et al.
Publicado: (2020)

Vascular Endothelial Over-Expression of Human Soluble Epoxide Hydrolase (Tie2-sEH Tr) Attenuates Coronary Reactive Hyperemia in Mice: Role of Oxylipins and ω-Hydroxylases
por: Hanif, Ahmad, et al.
Publicado: (2017)

COX-2/sEH Dual Inhibitor Alleviates Hepatocyte Senescence in NAFLD Mice by Restoring Autophagy through Sirt1/PI3K/AKT/mTOR
por: Zhang, Chen-Yu, et al.
Publicado: (2022)

Targeting IRE1α-JNK-c-Jun/AP-1-sEH Signaling Pathway Improves Myocardial and Coronary Endothelial Function Following Global Myocardial Ischemia/Reperfusion
por: Xue, Hong-Mei, et al.
Publicado: (2022)

Dissecting the Regulation of Arachidonic Acid Metabolites by Uncaria rhynchophylla (Miq). Miq. in Spontaneously Hypertensive Rats and the Predictive Target sEH in the Anti-Hypertensive Effect Based on Metabolomics and Molecular Docking
por: Gao, Lei, et al.
Publicado: (2022)

3 Vragen over Opleidingsboost op de seh
Publicado: (2020)

COX-2/sEH Dual Inhibitor PTUPB Attenuates Epithelial-Mesenchymal Transformation of Alveolar Epithelial Cells via Nrf2-Mediated Inhibition of TGF-β1/Smad Signaling
por: Zhang, Chen-Yu, et al.
Publicado: (2022)

Slicer EPA HR.SEH 21 : Commande de mouvement
por: Metral, G
Publicado: (1988)

Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol
por: Noha, Stefan M., et al.
Publicado: (2015)

Pretargeted Imaging with Gallium-68—Improving the Binding Capability by Increasing the Number of Tetrazine Motifs
por: Summer, Dominik, et al.
Publicado: (2018)

Nucleoporins Nup160 and Seh1 are required for disease resistance in Arabidopsis
por: Roth, Charlotte, et al.
Publicado: (2012)

Seh1 targets GATOR2 and Nup153 to mitotic chromosomes
por: Platani, Melpomeni, et al.
Publicado: (2018)

Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction
por: Mayr, Fabian, et al.
Publicado: (2020)

Perspective: Postoperative spinal epidural hematomas (pSEH) should be treated, not ignored
por: Epstein, Nancy E., et al.
Publicado: (2023)

The layout of EHS
por: Montanet, Lucien, et al.
Publicado: (1976)

EHS Symposium
Publicado: (1986)

The layout of EHS
por: Montanet, L, et al.
Publicado: (1976)

Ginkgolic Acid is a Multi-Target Inhibitor of Key Enzymes in Pro-Inflammatory Lipid Mediator Biosynthesis
por: Gerstmeier, Jana, et al.
Publicado: (2019)

Procédure de consignation, de déconsignation et d’utilisation des générateurs haute tension 300 kV des septa electrostatiques PE.SEH 23 et PE.SEH 31
por: Hugot, B, et al.
Publicado: (2000)

Cannot write session to /tmp/vufind_sessions/sess_2bhj64mpfborc1hi9ouluaset5