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Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a master regulator of cell growth and metabolism. Leucine (Leu) activates mTORC1 and many have tried to identify the mechanisms whereby cells sense Leu in this context. Here we describe that the Leu metabolite acetyl-coenzyme A (AcCoA)...

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Detalles Bibliográficos
Autores principales:	Son, Sung Min, Park, So Jung, Lee, Huikyong, Siddiqi, Farah, Lee, Jong Eun, Menzies, Fiona M., Rubinsztein, David C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331339/ https://www.ncbi.nlm.nih.gov/pubmed/30197302 http://dx.doi.org/10.1016/j.cmet.2018.08.013

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