Cargando…

SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy

NFATc4, a member from the Nuclear Factor of Activated T cells (NFATs) transcription factor family, plays a pivotal role in the development of cardiac hypertrophy. NFATc4 is dephosphorylated by calcineurin and translocated from the cytoplasm to the nucleus to regulate the expression of hypertrophic g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Zhenzhen, Zhang, Xiaoying, Guo, Zhen, Zhong, Yao, Wang, Panxia, Li, Jingyan, Li, Zhuoming, Liu, Peiqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331469/ https://www.ncbi.nlm.nih.gov/pubmed/30670969 http://dx.doi.org/10.3389/fphar.2018.01519

Ejemplares similares

PRMT5 Prevents Cardiomyocyte Hypertrophy via Symmetric Dimethylating HoxA9 and Repressing HoxA9 Expression
por: Cai, Sidong, et al.
Publicado: (2020)

Epigenetic Reader Bromodomain Containing Protein 2 Facilitates Pathological Cardiac Hypertrophy via Regulating the Expression of Citrate Cycle Genes
por: Lin, Zhirong, et al.
Publicado: (2022)

The poly(ADP-ribosyl)ation of BRD4 mediated by PARP1 promoted pathological cardiac hypertrophy
por: Li, Zhenzhen, et al.
Publicado: (2021)

The cross-talk between PARylation and SUMOylation in C/EBPβ at K134 site participates in pathological cardiac hypertrophy
por: Wang, Luping, et al.
Publicado: (2022)

SIRT3 improved peroxisomes-mitochondria interplay and prevented cardiac hypertrophy via preserving PEX5 expression
por: Wang, Minghui, et al.
Publicado: (2023)

Histone Demethylase JMJD3 Mediated Doxorubicin-Induced Cardiomyopathy by Suppressing SESN2 Expression
por: Wang, Panxia, et al.
Publicado: (2020)

Spironolactone Inhibits Cardiomyocyte Hypertrophy by Regulating the Ca(2+)/Calcineurin/p-NFATc3 Pathway
por: Wang, Xin, et al.
Publicado: (2021)

Shengmai Injection Suppresses Angiotensin II-Induced Cardiomyocyte Hypertrophy and Apoptosis via Activation of the AMPK Signaling Pathway Through Energy-Dependent Mechanisms
por: Li, Yiping, et al.
Publicado: (2019)

A Nitrobenzoyl Sesquiterpenoid Insulicolide A Prevents Osteoclast Formation via Suppressing c-Fos-NFATc1 Signaling Pathway
por: Tan, Yanhui, et al.
Publicado: (2022)

The Double-Edged Sword of SIRT3 in Cancer and Its Therapeutic Applications
por: Ouyang, Shumin, et al.
Publicado: (2022)

Quercetin Attenuates Cardiac Hypertrophy by Inhibiting Mitochondrial Dysfunction Through SIRT3/PARP-1 Pathway
por: Chen, Wen-Jing, et al.
Publicado: (2021)

Salidroside Ameliorates Cardiomyocyte Hypertrophy by Upregulating Peroxisome Proliferator-Activated Receptor-α
por: Gao, Hui, et al.
Publicado: (2022)

6′-O-Galloylpaeoniflorin Attenuates Osteoclasto-genesis and Relieves Ovariectomy-Induced Osteoporosis by Inhibiting Reactive Oxygen Species and MAPKs/c-Fos/NFATc1 Signaling Pathway
por: Liu, Wenjie, et al.
Publicado: (2021)

MiR-27a-3p/Hoxa10 Axis Regulates Angiotensin II-Induced Cardiomyocyte Hypertrophy by Targeting Kv4.3 Expression
por: Cao, Xuefeng, et al.
Publicado: (2021)

Betulinic Acid Protects From Bone Loss in Ovariectomized Mice and Suppresses RANKL-Associated Osteoclastogenesis by Inhibiting the MAPK and NFATc1 Pathways
por: Wei, Jiyong, et al.
Publicado: (2020)

TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy
por: Sunggip, Caroline, et al.
Publicado: (2018)

Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation
por: Lu, Jing, et al.
Publicado: (2019)

Inhibitory Effects of Rhaponticin on Osteoclast Formation and Resorption by Targeting RANKL-Induced NFATc1 and ROS Activity
por: He, Jianbo, et al.
Publicado: (2021)

Trypsin inhibitor LH011 inhibited DSS-induced mice colitis via alleviating inflammation and oxidative stress
por: Jia, Zhenmao, et al.
Publicado: (2022)

Parkia speciosa Hassk. Empty Pod Extract Prevents Cardiomyocyte Hypertrophy by Inhibiting MAPK and Calcineurin-NFATC3 Signaling Pathways
por: Mustafa, Nor Hidayah, et al.
Publicado: (2022)

Luteolin suppresses lipopolysaccharide-induced cardiomyocyte hypertrophy and autophagy in vitro
por: Li, Xing, et al.
Publicado: (2019)

Network Pharmacology and In Vitro Experimental Verification Reveal the Mechanism of the Hirudin in Suppressing Myocardial Hypertrophy
por: Liu, Mengnan, et al.
Publicado: (2022)

Pharmacological suppression of Nedd4-2 rescues the reduction of Kv11.1 channels in pathological cardiac hypertrophy
por: Zhang, Hua, et al.
Publicado: (2022)

Deubiquitinase Ubiquitin‐Specific Protease 10 Deficiency Regulates Sirt6 signaling and Exacerbates Cardiac Hypertrophy
por: Zhang, Dian‐Hong, et al.
Publicado: (2020)

Dapagliflozin Mediates Plin5/PPARα Signaling Axis to Attenuate Cardiac Hypertrophy
por: Yu, Jing, et al.
Publicado: (2021)

Corydalis Saxicola Bunting Total Alkaloids Attenuate Walker 256-Induced Bone Pain and Osteoclastogenesis by Suppressing RANKL-Induced NF-κB and c-Fos/NFATc1 Pathways in Rats
por: Ju, Linjie, et al.
Publicado: (2021)

Mogroside IIe Ameliorates Cardiomyopathy by Suppressing Cardiomyocyte Apoptosis in a Type 2 Diabetic Model
por: Cai, Xin, et al.
Publicado: (2021)

Mitochondrial Fission Is Required for Angiotensin II-Induced Cardiomyocyte Apoptosis Mediated by a Sirt1-p53 Signaling Pathway
por: Qi, Jia, et al.
Publicado: (2018)

KMUP-1 Attenuates Endothelin-1-Induced Cardiomyocyte Hypertrophy through Activation of Heme Oxygenase-1 and Suppression of the Akt/GSK-3β, Calcineurin/NFATc4 and RhoA/ROCK Pathways
por: Liou, Shu-Fen, et al.
Publicado: (2015)

Tanshinone IIA Protects Against Cardiac Hypertrophy via Inhibiting Calcineurin/Nfatc3 Pathway
por: Tan, Xueying, et al.
Publicado: (2011)

SIRT1 Functions as an Important Regulator of Estrogen-Mediated Cardiomyocyte Protection in Angiotensin II-Induced Heart Hypertrophy
por: Shen, Tao, et al.
Publicado: (2014)

Herpud1 suppress angiotensin II induced hypertrophy in cardiomyocytes
por: Mikawa, Mei, et al.
Publicado: (2022)

SIRT6 overexpression retards renal interstitial fibrosis through targeting HIPK2 in chronic kidney disease
por: Li, Xiaoxue, et al.
Publicado: (2022)

Bawei Chenxiang Wan Ameliorates Cardiac Hypertrophy by Activating AMPK/PPAR-α Signaling Pathway Improving Energy Metabolism
por: Zhang, Xiaoying, et al.
Publicado: (2021)

SIRT6 Depletion Sensitizes Human Hepatoma Cells to Chemotherapeutics by Downregulating MDR1 Expression
por: Xia, Yang Q., et al.
Publicado: (2018)

Cardiac CaMKIIδ and Wenxin Keli Prevents Ang II-Induced Cardiomyocyte Hypertrophy by Modulating CnA-NFATc4 and Inflammatory Signaling Pathways in H9c2 Cells
por: An, Na, et al.
Publicado: (2020)

Gastrodin Inhibits Store-Operated Ca(2+) Entry and Alleviates Cardiac Hypertrophy
por: Zheng, Changbo, et al.
Publicado: (2017)

6-Bromoindirubin-3′-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver
por: Guo, Donghao, et al.
Publicado: (2019)

Daphnetin Attenuated Cisplatin-Induced Acute Nephrotoxicity With Enhancing Antitumor Activity of Cisplatin by Upregulating SIRT1/SIRT6-Nrf2 Pathway
por: Fan, Xiaoye, et al.
Publicado: (2020)

STAT3 Suppresses Cardiomyocytes Apoptosis in CVB3-Induced Myocarditis Via Survivin
por: Wang, Qiaoyu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_bmo0csvdiccifrdu78q1q27pls