Cargando…
Dynamic genomic architecture of mutualistic cooperation in a wild population of Mesorhizobium
Research on mutualism seeks to explain how cooperation can be maintained when uncooperative mutants co-occur with cooperative kin. Gains and losses of the gene modules required for cooperation punctuate symbiont phylogenies and drive lifestyle transitions between cooperative symbionts and uncooperat...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331556/ https://www.ncbi.nlm.nih.gov/pubmed/30218020 http://dx.doi.org/10.1038/s41396-018-0266-y |
_version_ | 1783387157693464576 |
---|---|
author | Porter, Stephanie S. Faber-Hammond, Joshua Montoya, Angeliqua P. Friesen, Maren L. Sackos, Cynthia |
author_facet | Porter, Stephanie S. Faber-Hammond, Joshua Montoya, Angeliqua P. Friesen, Maren L. Sackos, Cynthia |
author_sort | Porter, Stephanie S. |
collection | PubMed |
description | Research on mutualism seeks to explain how cooperation can be maintained when uncooperative mutants co-occur with cooperative kin. Gains and losses of the gene modules required for cooperation punctuate symbiont phylogenies and drive lifestyle transitions between cooperative symbionts and uncooperative free-living lineages over evolutionary time. Yet whether uncooperative symbionts commonly evolve from within cooperative symbiont populations or from within distantly related lineages with antagonistic or free-living lifestyles (i.e., third-party mutualism exploiters or parasites), remains controversial. We use genomic data to show that genotypes that differ in the presence or absence of large islands of symbiosis genes are common within a single wild recombining population of Mesorhizobium symbionts isolated from host tissues and are an important source of standing heritable variation in cooperation in this population. In a focal population of Mesorhizobium, uncooperative variants that lack a symbiosis island segregate at 16% frequency in nodules, and genome size and symbiosis gene number are positively correlated with cooperation. This finding contrasts with the genomic architecture of variation in cooperation in other symbiont populations isolated from host tissues in which the islands of genes underlying cooperation are ubiquitous and variation in cooperation is primarily driven by allelic substitution and individual gene gain and loss events. Our study demonstrates that uncooperative mutants within mutualist populations can comprise a significant component of genetic variation in nature, providing biological rationale for models and experiments that seek to explain the maintenance of mutualism in the face of non-cooperators. |
format | Online Article Text |
id | pubmed-6331556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63315562019-01-15 Dynamic genomic architecture of mutualistic cooperation in a wild population of Mesorhizobium Porter, Stephanie S. Faber-Hammond, Joshua Montoya, Angeliqua P. Friesen, Maren L. Sackos, Cynthia ISME J Article Research on mutualism seeks to explain how cooperation can be maintained when uncooperative mutants co-occur with cooperative kin. Gains and losses of the gene modules required for cooperation punctuate symbiont phylogenies and drive lifestyle transitions between cooperative symbionts and uncooperative free-living lineages over evolutionary time. Yet whether uncooperative symbionts commonly evolve from within cooperative symbiont populations or from within distantly related lineages with antagonistic or free-living lifestyles (i.e., third-party mutualism exploiters or parasites), remains controversial. We use genomic data to show that genotypes that differ in the presence or absence of large islands of symbiosis genes are common within a single wild recombining population of Mesorhizobium symbionts isolated from host tissues and are an important source of standing heritable variation in cooperation in this population. In a focal population of Mesorhizobium, uncooperative variants that lack a symbiosis island segregate at 16% frequency in nodules, and genome size and symbiosis gene number are positively correlated with cooperation. This finding contrasts with the genomic architecture of variation in cooperation in other symbiont populations isolated from host tissues in which the islands of genes underlying cooperation are ubiquitous and variation in cooperation is primarily driven by allelic substitution and individual gene gain and loss events. Our study demonstrates that uncooperative mutants within mutualist populations can comprise a significant component of genetic variation in nature, providing biological rationale for models and experiments that seek to explain the maintenance of mutualism in the face of non-cooperators. Nature Publishing Group UK 2018-09-14 2019-02 /pmc/articles/PMC6331556/ /pubmed/30218020 http://dx.doi.org/10.1038/s41396-018-0266-y Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Porter, Stephanie S. Faber-Hammond, Joshua Montoya, Angeliqua P. Friesen, Maren L. Sackos, Cynthia Dynamic genomic architecture of mutualistic cooperation in a wild population of Mesorhizobium |
title | Dynamic genomic architecture of mutualistic cooperation in a wild population of Mesorhizobium |
title_full | Dynamic genomic architecture of mutualistic cooperation in a wild population of Mesorhizobium |
title_fullStr | Dynamic genomic architecture of mutualistic cooperation in a wild population of Mesorhizobium |
title_full_unstemmed | Dynamic genomic architecture of mutualistic cooperation in a wild population of Mesorhizobium |
title_short | Dynamic genomic architecture of mutualistic cooperation in a wild population of Mesorhizobium |
title_sort | dynamic genomic architecture of mutualistic cooperation in a wild population of mesorhizobium |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331556/ https://www.ncbi.nlm.nih.gov/pubmed/30218020 http://dx.doi.org/10.1038/s41396-018-0266-y |
work_keys_str_mv | AT porterstephanies dynamicgenomicarchitectureofmutualisticcooperationinawildpopulationofmesorhizobium AT faberhammondjoshua dynamicgenomicarchitectureofmutualisticcooperationinawildpopulationofmesorhizobium AT montoyaangeliquap dynamicgenomicarchitectureofmutualisticcooperationinawildpopulationofmesorhizobium AT friesenmarenl dynamicgenomicarchitectureofmutualisticcooperationinawildpopulationofmesorhizobium AT sackoscynthia dynamicgenomicarchitectureofmutualisticcooperationinawildpopulationofmesorhizobium |