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Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis

Whether sensory nerve can sense bone density or metabolic activity to control bone homeostasis is unknown. Here we found prostaglandin E2 (PGE2) secreted by osteoblastic cells activates PGE2 receptor 4 (EP4) in sensory nerves to regulate bone formation by inhibiting sympathetic activity through the...

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Detalles Bibliográficos
Autores principales:	Chen, Hao, Hu, Bo, Lv, Xiao, Zhu, Shouan, Zhen, Gehua, Wan, Mei, Jain, Amit, Gao, Bo, Chai, Yu, Yang, Mi, Wang, Xiao, Deng, Ruoxian, Wang, Lei, Cao, Yong, Ni, Shuangfei, Liu, Shen, Yuan, Wen, Chen, Huajiang, Dong, Xinzhong, Guan, Yun, Yang, Huilin, Cao, Xu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331599/ https://www.ncbi.nlm.nih.gov/pubmed/30643142 http://dx.doi.org/10.1038/s41467-018-08097-7

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