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Flupirtine Analogues: Explorative Synthesis and Influence of Chemical Structure on K(V)7.2/K(V)7.3 Channel Opening Activity

Neuronal voltage‐gated potassium channels K(V)7.2/K(V)7.3 are sensitive to small‐molecule drugs such as flupirtine, even though physiological response occurs in the absence of ligands. Clinically, prolonged use of flupirtine as a pain medication is associated with rare cases of drug‐induced liver in...

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Detalles Bibliográficos
Autores principales:	Surur, Abdrrahman S., Beirow, Kristin, Bock, Christian, Schulig, Lukas, Kindermann, Markus K., Bodtke, Anja, Siegmund, Werner, Bednarski, Patrick J., Link, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331712/ https://www.ncbi.nlm.nih.gov/pubmed/30652063 http://dx.doi.org/10.1002/open.201800244

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