Development of XIAP Antagonists Based On De Novo 8,5‐Fused Bicyclic Lactams

In order to develop original water soluble antagonists of X‐linked inhibitor of apoptosis protein (XIAP), a novel bicyclic scaffold was designed based on 8,5‐fused bicyclic lactam. During its preparation, a spontaneous rearrangement from 8,5‐ to 7,5‐fused bicyclic lactam was observed and confirmed b...

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Detalles Bibliográficos
Autores principales: Sheng, Zhaojun J., Shi, Yiming M., Xu, Ximing, Bellynck, Sébastien, Zhang, Kun, Du, Zhiyun Y., Xu, Xuetao, Maurel, François, Dong, Chang‐Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331714/
https://www.ncbi.nlm.nih.gov/pubmed/30652062
http://dx.doi.org/10.1002/open.201800260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331714/
https://www.ncbi.nlm.nih.gov/pubmed/30652062
http://dx.doi.org/10.1002/open.201800260

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