Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self‐reactive plasma cells

The transcription factor Blimp1 is not only an essential regulator of plasma cells, but also a risk factor for the development of autoimmune disease in humans. Here, we demonstrate in the mouse that the Prdm1 (Blimp1) gene was partially activated at the chromatin and transcription level in early B c...

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Detalles Bibliográficos
Autores principales: Bönelt, Peter, Wöhner, Miriam, Minnich, Martina, Tagoh, Hiromi, Fischer, Maria, Jaritz, Markus, Kavirayani, Anoop, Garimella, Manasa, Karlsson, Mikael CI, Busslinger, Meinrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331720/
https://www.ncbi.nlm.nih.gov/pubmed/30498131
http://dx.doi.org/10.15252/embj.2018100010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331720/
https://www.ncbi.nlm.nih.gov/pubmed/30498131
http://dx.doi.org/10.15252/embj.2018100010

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