Limonoids from the Seeds of Swietenia macrophylla and Their Anti-Inflammatory Activities

A new limonoid, swietemacrophin (1), was isolated from the seeds of Swietenia macrophylla, together with five known compounds 2–6. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Swietemacrophin (1), humilinolide F (2), 3,6-O,O-diacetylswietenolide (3),...

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Detalles Bibliográficos
Autores principales: Chen, Li-Chai, Liao, Hsiang-Ruei, Chen, Pei-Yu, Kuo, Wen-Lung, Chang, Tsung-Hsien, Sung, Ping-Jyun, Wen, Zhi-Hong, Chen, Jih-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331795/
https://www.ncbi.nlm.nih.gov/pubmed/26473818
http://dx.doi.org/10.3390/molecules201018551
Descripción
Sumario:A new limonoid, swietemacrophin (1), was isolated from the seeds of Swietenia macrophylla, together with five known compounds 2–6. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Swietemacrophin (1), humilinolide F (2), 3,6-O,O-diacetylswietenolide (3), 3-O-tigloylswietenolide (4), and swietemahonin E (5) exhibited inhibition (IC(50) values ≤ 45.44 μM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP). Compounds 1, 4, 5, and swietenine (6) showed potent inhibition with IC(50) values ≤ 36.32 μM, against lipopolysaccharide (LPS)-induced nitric oxide (NO) generation.

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