Cargando…

Protective Effects of Red Guava on Inflammation and Oxidative Stress in Streptozotocin-Induced Diabetic Mice

Diabetes is an important chronic disease and the 4th leading cause of death in Taiwan. Hyperglycemia-induced oxidative and inflammatory damage are the main causes of chronic complications in diabetic patients. The red guava (red-fleshed guava cultivar of Psidium guajava L.) is a tropical fruit belon...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Pei-Ying, Hsu, Cheng-Chin, Yin, Mei-Chin, Kuo, Yueh-Hsiung, Tang, Feng-Yao, Chao, Che-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331796/
https://www.ncbi.nlm.nih.gov/pubmed/26703532
http://dx.doi.org/10.3390/molecules201219831
_version_ 1783387199611338752
author Li, Pei-Ying
Hsu, Cheng-Chin
Yin, Mei-Chin
Kuo, Yueh-Hsiung
Tang, Feng-Yao
Chao, Che-Yi
author_facet Li, Pei-Ying
Hsu, Cheng-Chin
Yin, Mei-Chin
Kuo, Yueh-Hsiung
Tang, Feng-Yao
Chao, Che-Yi
author_sort Li, Pei-Ying
collection PubMed
description Diabetes is an important chronic disease and the 4th leading cause of death in Taiwan. Hyperglycemia-induced oxidative and inflammatory damage are the main causes of chronic complications in diabetic patients. The red guava (red-fleshed guava cultivar of Psidium guajava L.) is a tropical fruit belonging to the Myrtaceae family and an important commercial crop in Taiwan. In this study, the protective effects of a diet containing red guava on inflammation and oxidative stress in streptozotocin (STZ)-induced diabetic mice were examined. The experimental group was divided into seven subgroups: normal (N), diabetes mellitus (DM), diabetes + red guava 1% (L), 2% (M), and 5% (H), diabetes + 5% red guava + anti-diabetic rosiglitazone (HR), and diabetes + anti-diabetic rosiglitazone (R). The mice were fed for 8 weeks and sacrificed by decapitation. Compared with the DM group, the experimental groups with diets containing red guava as well as rosiglitazone all showed significant improvements in blood glucose control, insulin resistance, creatinine, blood urea nitrogen, triglycerides, non-esterified fatty acids, cholesterol, c-reactive protein, TNF-α, and IL-10. Furthermore, the expression of inflammatory proteins, such as iNOS and NF-κB, was suppressed via activated PPARγ, and the expression levels of GPx3 and ACO increased. In summary, red guava can significantly suppress inflammatory and oxidative damage caused by diabetes and alleviate diabetic symptoms; thus, it exerts protective effects and has potential applications for the development of a dietary supplement.
format Online
Article
Text
id pubmed-6331796
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-63317962019-01-24 Protective Effects of Red Guava on Inflammation and Oxidative Stress in Streptozotocin-Induced Diabetic Mice Li, Pei-Ying Hsu, Cheng-Chin Yin, Mei-Chin Kuo, Yueh-Hsiung Tang, Feng-Yao Chao, Che-Yi Molecules Article Diabetes is an important chronic disease and the 4th leading cause of death in Taiwan. Hyperglycemia-induced oxidative and inflammatory damage are the main causes of chronic complications in diabetic patients. The red guava (red-fleshed guava cultivar of Psidium guajava L.) is a tropical fruit belonging to the Myrtaceae family and an important commercial crop in Taiwan. In this study, the protective effects of a diet containing red guava on inflammation and oxidative stress in streptozotocin (STZ)-induced diabetic mice were examined. The experimental group was divided into seven subgroups: normal (N), diabetes mellitus (DM), diabetes + red guava 1% (L), 2% (M), and 5% (H), diabetes + 5% red guava + anti-diabetic rosiglitazone (HR), and diabetes + anti-diabetic rosiglitazone (R). The mice were fed for 8 weeks and sacrificed by decapitation. Compared with the DM group, the experimental groups with diets containing red guava as well as rosiglitazone all showed significant improvements in blood glucose control, insulin resistance, creatinine, blood urea nitrogen, triglycerides, non-esterified fatty acids, cholesterol, c-reactive protein, TNF-α, and IL-10. Furthermore, the expression of inflammatory proteins, such as iNOS and NF-κB, was suppressed via activated PPARγ, and the expression levels of GPx3 and ACO increased. In summary, red guava can significantly suppress inflammatory and oxidative damage caused by diabetes and alleviate diabetic symptoms; thus, it exerts protective effects and has potential applications for the development of a dietary supplement. MDPI 2015-12-12 /pmc/articles/PMC6331796/ /pubmed/26703532 http://dx.doi.org/10.3390/molecules201219831 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Pei-Ying
Hsu, Cheng-Chin
Yin, Mei-Chin
Kuo, Yueh-Hsiung
Tang, Feng-Yao
Chao, Che-Yi
Protective Effects of Red Guava on Inflammation and Oxidative Stress in Streptozotocin-Induced Diabetic Mice
title Protective Effects of Red Guava on Inflammation and Oxidative Stress in Streptozotocin-Induced Diabetic Mice
title_full Protective Effects of Red Guava on Inflammation and Oxidative Stress in Streptozotocin-Induced Diabetic Mice
title_fullStr Protective Effects of Red Guava on Inflammation and Oxidative Stress in Streptozotocin-Induced Diabetic Mice
title_full_unstemmed Protective Effects of Red Guava on Inflammation and Oxidative Stress in Streptozotocin-Induced Diabetic Mice
title_short Protective Effects of Red Guava on Inflammation and Oxidative Stress in Streptozotocin-Induced Diabetic Mice
title_sort protective effects of red guava on inflammation and oxidative stress in streptozotocin-induced diabetic mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331796/
https://www.ncbi.nlm.nih.gov/pubmed/26703532
http://dx.doi.org/10.3390/molecules201219831
work_keys_str_mv AT lipeiying protectiveeffectsofredguavaoninflammationandoxidativestressinstreptozotocininduceddiabeticmice
AT hsuchengchin protectiveeffectsofredguavaoninflammationandoxidativestressinstreptozotocininduceddiabeticmice
AT yinmeichin protectiveeffectsofredguavaoninflammationandoxidativestressinstreptozotocininduceddiabeticmice
AT kuoyuehhsiung protectiveeffectsofredguavaoninflammationandoxidativestressinstreptozotocininduceddiabeticmice
AT tangfengyao protectiveeffectsofredguavaoninflammationandoxidativestressinstreptozotocininduceddiabeticmice
AT chaocheyi protectiveeffectsofredguavaoninflammationandoxidativestressinstreptozotocininduceddiabeticmice