Cargando…

Anti-Lymphoma Efficacy Comparison of Anti-CD20 Monoclonal Antibody-Targeted and Non-Targeted Star-Shaped Polymer-Prodrug Conjugates

Here we describe the synthesis and biological properties of two types of star-shaped polymer-doxorubicin conjugates: non-targeted conjugate prepared as long-circulating high-molecular-weight (HMW) polymer prodrugs with a dendrimer core and a targeted conjugate with the anti-CD20 monoclonal antibody...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lidický, Ondřej, Janoušková, Olga, Strohalm, Jiří, Alam, Mahmudul, Klener, Pavel, Etrych, Tomáš
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331818/ https://www.ncbi.nlm.nih.gov/pubmed/26556320 http://dx.doi.org/10.3390/molecules201119664

Ejemplares similares

Targeted Drug Delivery and Theranostic Strategies in Malignant Lymphomas
por: Etrych, Tomas, et al.
Publicado: (2022)

Plasma clearance of an antibody--enzyme conjugate in ADEPT by monoclonal anti-enzyme: its effect on prodrug activation in vivo.
por: Rogers, G. T., et al.
Publicado: (1995)

Reinvestigation of the Automated Synthesis of Stoichiometrically Conjugated Antibodies to Access High Molecular Weight Payloads and Multiplexed Conjugation via an In-Solution Trans-Tagging Process
por: Lehot, Victor, et al.
Publicado: (2023)

Tumour tropism and anti-cancer efficacy of polymer-based doxorubicin prodrugs in the treatment of subcutaneous murine B16F10 melanoma.
por: Seymour, L. W., et al.
Publicado: (1994)

Octreotide-periplocymarin conjugate prodrug for improving targetability and anti-tumor efficiency: synthesis, in vitro and in vivo evaluation
por: Zhang, Hui-Yun, et al.
Publicado: (2016)

CD163 Monoclonal Antibody Modified Polymer Prodrug Nanoparticles for Targeting Tumor-Associated Macrophages (TAMs) to Enhance Anti-Tumor Effects
por: Yang, Zun, et al.
Publicado: (2023)

Glutathione S-conjugates as prodrugs to target drug-resistant tumors
por: Ramsay, Emma E., et al.
Publicado: (2014)

Fluorescence Imaging as a Tool in Preclinical Evaluation of Polymer-Based Nano-DDS Systems Intended for Cancer Treatment
por: Etrych, Tomáš, et al.
Publicado: (2019)

Potential Development of Tumor-Targeted Oral Anti-Cancer Prodrugs: Amino Acid and Dipeptide Monoester Prodrugs of Gemcitabine
por: Tsume, Yasuhiro, et al.
Publicado: (2017)

Functional cRGD-Conjugated Polymer Prodrug for Targeted Drug Delivery to Liver Cancer Cells
por: Zhou, Ru, et al.
Publicado: (2022)

Redox-Responsive Heparin–Chlorambucil Conjugate Polymeric Prodrug for Improved Anti-Tumor Activity
por: Andrgie, Abegaz Tizazu, et al.
Publicado: (2019)

Advances in Molecular Biology and Targeted Therapy of Mantle Cell Lymphoma
por: Klener, Pavel
Publicado: (2019)

Phospholipid prodrug conjugates of insoluble chemotherapeutic agents for ultrasound targeted drug delivery
por: Márquez, Mendi G., et al.
Publicado: (2020)

Monoclonal antibodies targeting CD20
por: Chang, Chien-Hsing, et al.
Publicado: (2013)

Evaluation of Nitrobenzyl Derivatives of Camptothecin as Anti-Cancer Agents and Potential Hypoxia Targeting Prodrugs
por: Liang, Dinghua, et al.
Publicado: (2018)

Anti-tumour effects of an antibody-carboxypeptidase G2 conjugate in combination with phenol mustard prodrugs.
por: Blakey, D. C., et al.
Publicado: (1995)

Anti-PD-L1 peptide-conjugated prodrug nanoparticles for targeted cancer immunotherapy combining PD-L1 blockade with immunogenic cell death
por: Moon, Yujeong, et al.
Publicado: (2022)

Anti-CD47 Monoclonal Antibody–Drug Conjugate: A Targeted Therapy to Treat Triple-Negative Breast Cancers
por: Si, Yingnan, et al.
Publicado: (2021)

Ruptured Thoracolumbar Perimedullary Arteriovenous Fistula during Pregnancy Complicated by Cerebral Subarachnoid Hemorrhage and Brainstem Hematoma: A Case Report
por: Sroubek, Jan, et al.
Publicado: (2020)

Cisplatin Prodrug-Conjugated Gold Nanocluster for Fluorescence Imaging and Targeted Therapy of the Breast Cancer
por: Zhou, Fangyuan, et al.
Publicado: (2016)

Cyclic Ruthenium-Peptide Conjugates as Integrin-Targeting Phototherapeutic Prodrugs for the Treatment of Brain Tumors
por: Zhang, Liyan, et al.
Publicado: (2023)

Response to: Monoclonal antibodies targeting CD20
por: Klein, Christian, et al.
Publicado: (2013)

A monoclonal antibody-beta-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for specific treatment of cancer.
por: Haisma, H. J., et al.
Publicado: (1992)

Detailed Functional and Proteomic Characterization of Fludarabine Resistance in Mantle Cell Lymphoma Cells
por: Lorkova, Lucie, et al.
Publicado: (2015)

Gold nanoparticles conjugated with anti-CD133 monoclonal antibody and 5-fluorouracil chemotherapeutic agent as nanocarriers for cancer cell targeting
por: Mohd-Zahid, Manali Haniti, et al.
Publicado: (2021)

Ofatumumab: a novel monoclonal anti-CD20 antibody
por: Lin, Thomas S
Publicado: (2010)

Anti-CD20 monoclonal antibodies: reviewing a revolution
por: Casan, J. M. L., et al.
Publicado: (2018)

From prodrug to pro-prodrug: hypoxia-sensitive antibody–drug conjugates
por: Wang, Yanming, et al.
Publicado: (2022)

Toward Multitasking Pharmacological COX-Targeting Agents: Non-Steroidal Anti-Inflammatory Prodrugs with Antiproliferative Effects
por: Grande, Fedora, et al.
Publicado: (2021)

A New Form of Specific Targeting Cancer Immunotherapy Using Anti‐tumor Monoclonal Antibody‐conjugated Lymphokine‐activated Killer Cells
por: Shiraiwa, Hiroshi, et al.
Publicado: (1991)

A Review of Anti-Angiogenic Targets for Monoclonal Antibody Cancer Therapy
por: Kong, Deok-Hoon, et al.
Publicado: (2017)

Targeted Polymer-Based Probes for Fluorescence Guided Visualization and Potential Surgery of EGFR-Positive Head-and-Neck Tumors
por: Pola, Robert, et al.
Publicado: (2020)

Tumor Stimulus-Responsive Biodegradable Diblock Copolymer Conjugates as Efficient Anti-Cancer Nanomedicines
por: Šubr, Vladimír, et al.
Publicado: (2022)

Polymer Cancerostatics Containing Cell-Penetrating Peptides: Internalization Efficacy Depends on Peptide Type and Spacer Length
por: Böhmová, Eliška, et al.
Publicado: (2020)

Novel Prodrugs for Targeting Diagnostic and Therapeutic Radionuclides to Solid Tumors
por: Kassis, Amin I., et al.
Publicado: (2008)

Folic acid–conjugated mesoporous silica particles as nanocarriers of natural prodrugs for cancer targeting and antioxidant action
por: AbouAitah, Khaled, et al.
Publicado: (2018)

A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates
por: Sun, Yixin, et al.
Publicado: (2019)

Tuberculosis dissemination in kidney transplant recipient treated with anti-CD40 monoclonal antibody: a case report
por: Bednarova, Kamila, et al.
Publicado: (2022)

Cytomegalovirus Protease Targeted Prodrug Development
por: Sabit, Hairat, et al.
Publicado: (2013)

HPMA-Based Polymer Conjugates for Repurposed Drug Mebendazole and Other Imidazole-Based Therapeutics
por: Studenovský, Martin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_8tcf38n5fagdga2l3kvf49pgt4