Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities

Recent studies focusing on identifying the biological agents of Catharsius molossus have led to the identification of three new N-acetyldopamine dimers molossusamide A–C (1−3) and two known compounds 4 and 5. The structures of the new compounds were identified by comprehensive spectroscopic evidence...

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Detalles Bibliográficos
Autores principales: Lu, Juan, Sun, Qin, Tu, Zheng-Chao, Lv, Qing, Shui, Pi-Xian, Cheng, Yong-Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331819/
https://www.ncbi.nlm.nih.gov/pubmed/26343619
http://dx.doi.org/10.3390/molecules200915589
Descripción
Sumario:Recent studies focusing on identifying the biological agents of Catharsius molossus have led to the identification of three new N-acetyldopamine dimers molossusamide A–C (1−3) and two known compounds 4 and 5. The structures of the new compounds were identified by comprehensive spectroscopic evidences. Compound 4 was found to have inhibitory effects towards COX-1 and COX-2.

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