Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities

Recent studies focusing on identifying the biological agents of Catharsius molossus have led to the identification of three new N-acetyldopamine dimers molossusamide A–C (1−3) and two known compounds 4 and 5. The structures of the new compounds were identified by comprehensive spectroscopic evidence...

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Autores principales: Lu, Juan, Sun, Qin, Tu, Zheng-Chao, Lv, Qing, Shui, Pi-Xian, Cheng, Yong-Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331819/
https://www.ncbi.nlm.nih.gov/pubmed/26343619
http://dx.doi.org/10.3390/molecules200915589
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author Lu, Juan
Sun, Qin
Tu, Zheng-Chao
Lv, Qing
Shui, Pi-Xian
Cheng, Yong-Xian
author_facet Lu, Juan
Sun, Qin
Tu, Zheng-Chao
Lv, Qing
Shui, Pi-Xian
Cheng, Yong-Xian
author_sort Lu, Juan
collection PubMed
description Recent studies focusing on identifying the biological agents of Catharsius molossus have led to the identification of three new N-acetyldopamine dimers molossusamide A–C (1−3) and two known compounds 4 and 5. The structures of the new compounds were identified by comprehensive spectroscopic evidences. Compound 4 was found to have inhibitory effects towards COX-1 and COX-2.
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spelling pubmed-63318192019-01-24 Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities Lu, Juan Sun, Qin Tu, Zheng-Chao Lv, Qing Shui, Pi-Xian Cheng, Yong-Xian Molecules Article Recent studies focusing on identifying the biological agents of Catharsius molossus have led to the identification of three new N-acetyldopamine dimers molossusamide A–C (1−3) and two known compounds 4 and 5. The structures of the new compounds were identified by comprehensive spectroscopic evidences. Compound 4 was found to have inhibitory effects towards COX-1 and COX-2. MDPI 2015-08-27 /pmc/articles/PMC6331819/ /pubmed/26343619 http://dx.doi.org/10.3390/molecules200915589 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lu, Juan
Sun, Qin
Tu, Zheng-Chao
Lv, Qing
Shui, Pi-Xian
Cheng, Yong-Xian
Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities
title Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities
title_full Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities
title_fullStr Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities
title_full_unstemmed Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities
title_short Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities
title_sort identification of n-acetyldopamine dimers from the dung beetle catharsius molossus and their cox-1 and cox-2 inhibitory activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331819/
https://www.ncbi.nlm.nih.gov/pubmed/26343619
http://dx.doi.org/10.3390/molecules200915589
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