Cargando…

New Diethyl Ammonium Salt of Thiobarbituric Acid Derivative: Synthesis, Molecular Structure Investigations and Docking Studies

The synthesis of the new diethyl ammonium salt of diethylammonium(E)-5-(1,5-bis(4-fluorophenyl)-3-oxopent-4-en-1-yl)-1,3-diethyl-4,6-dioxo-2-thioxohexaydropyrimidin-5-ide 3 via a regioselective Michael addition of N,N-diethylthiobarbituric acid 1 to dienone 2 is described. In 3, the carboanion of th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barakat, Assem, Al-Majid, Abdullah Mohammed, Soliman, Saied M., Lotfy, Gehad, Ghabbour, Hazem A., Fun, Hoong-Kun, Wadood, Abdul, Warad, Ismail, Sloop, Joseph C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331823/ https://www.ncbi.nlm.nih.gov/pubmed/26610441 http://dx.doi.org/10.3390/molecules201119710

Ejemplares similares

Structural and spectral investigations of the recently synthesized chalcone (E)-3-mesityl-1-(naphthalen-2-yl) prop-2-en-1-one, a potential chemotherapeutic agent
por: Barakat, Assem, et al.
Publicado: (2015)

Synthesis, Spectroscopic Investigations (X-ray, NMR and TD-DFT), Antimicrobial Activity and Molecular Docking of 2,6-Bis(hydroxy(phenyl)methyl)cyclohexanone
por: Barakat, Assem, et al.
Publicado: (2015)

Synthesis of Pyrazole-Thiobarbituric Acid Derivatives: Antimicrobial Activity and Docking Studies
por: Elshaier, Yaseen A. M. M., et al.
Publicado: (2016)

Vibrational spectral analysis, XRD-structure, computation, exo⇔endo isomerization and non-linear optical crystal of 5-((5-chloro-1H-indol-2-yl)methylene)-1,3-diethyl-2-thioxodihy-dropyrimidine-4,6 (1H,5H)-dione
por: Altowyan, Mezna Saleh, et al.
Publicado: (2019)

Design of New and Potent Diethyl Thiobarbiturates as Urease Inhibitors: A Computational Approach
por: Wadood, Abdul, et al.
Publicado: (2014)

Synthesis, Molecular Structure and Spectroscopic Investigations of Novel Fluorinated Spiro Heterocycles
por: Islam, Mohammad Shahidul, et al.
Publicado: (2015)

Synthesis, Crystal Structure and DFT Studies of a New Dinuclear Ag(I)-Malonamide Complex
por: Soliman, Saied M., et al.
Publicado: (2018)

Crystal structure of cyclohexylammonium thiocyanate
por: Bagabas, Abdulaziz A., et al.
Publicado: (2015)

Correction: Al-Majid, A.M., et al., Tandem Aldol-Michael Reactions in Aqueous Diethylamine Medium: A Greener and Efficient Approach to Bis-Pyrimidine Derivatives. Int. J. Mol. Sci. 2013, 14, 23762–23773.
por: Al-Majid, Abdullah M., et al.
Publicado: (2014)

Tandem Aldol-Michael Reactions in Aqueous Diethylamine Medium: A Greener and Efficient Approach to Bis-Pyrimidine Derivatives
por: Al-Majid, Abdullah M., et al.
Publicado: (2013)

A Greener, Efficient Approach to Michael Addition of Barbituric Acid to Nitroalkene in Aqueous Diethylamine Medium
por: Al-Najjar, Hany J., et al.
Publicado: (2014)

Unexpected formation of polymeric silver(I) complexes of azine-type ligand via self-assembly of Ag-salts with isatin oxamohydrazide
por: Soliman, Saied M., et al.
Publicado: (2018)

Tandem Aldol-Michael reactions in aqueous diethylamine medium: a greener and efficient approach to dimedone-barbituric acid derivatives
por: Barakat, Assem, et al.
Publicado: (2014)

THIOPENTONE AND OTHER THIOBARBITURATES
Publicado: (1956)

Synthesis, X-ray Diffraction, Thermogravimetric and DFT Analyses of Pyrimidine Derivatives
por: Barakat, Assem, et al.
Publicado: (2014)

Synthesis and characterisation of thiobarbituric acid enamine derivatives, and evaluation of their α-glucosidase inhibitory and anti-glycation activity
por: Ali, M., et al.
Publicado: (2020)

Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions
por: El Ashry, El Sayed H., et al.
Publicado: (2015)

Diethylammonium anilino(methoxy)phosphinate
por: Fu, Zhiyong, et al.
Publicado: (2008)

Ammonium O,O′-diethyl dithiophosphate
por: Okuniewski, Andrzej, et al.
Publicado: (2011)

Diethylammonium 4-hydroxybenzoate
por: Lu, Yong-Hong
Publicado: (2010)

Anticancer Indole-Based Chalcones: A Structural and Theoretical Analysis
por: Badria, Farid A., et al.
Publicado: (2019)

Decomposition of Intermolecular Interactions in the Crystal Structure of Some Diacetyl Platinum(II) Complexes: Combined Hirshfeld, AIM, and NBO Analyses
por: Soliman, Saied M., et al.
Publicado: (2016)

Variability of Thiobarbituric Acid Reacting Substances in Saliva
por: Behuliak, Michal, et al.
Publicado: (2009)

Chitosan–Thiobarbituric Acid: A Superadsorbent for Mercury
por: Bhatt, Rahul, et al.
Publicado: (2018)

5-Bromo-4-(3,4-dimethoxyphenyl)thiazol-2-amine
por: Ghabbour, Hazem A., et al.
Publicado: (2012)

Expeditious Green Synthesis of Novel 4-Methyl-1,2,5,6-tetraazafluoranthen-3(2H)-one Analogue from Ninhydrin: N/S-Alkylation and Aza-Michael Addition
por: Boraei, Ahmed T. A., et al.
Publicado: (2020)

Synthesis of New Functionalized Indoles Based on Ethyl Indol-2-carboxylate
por: Boraei, Ahmed T. A., et al.
Publicado: (2016)

(1E,4E)-1,5-Bis[4-(diethylamino)phenyl]penta-1,4-dien-3-one
por: Ruanwas, Pumsak, et al.
Publicado: (2014)

HPLC purification technique: synthesis of unsymmetrical thiobarbituric acids
por: Deotale, Vinod D., et al.
Publicado: (2019)

(E)-4-[4-(Diethylamino)benzylideneammonio]benzenesulfonate
por: Ruanwas, Pumsak, et al.
Publicado: (2012)

Diethyl(hydroxy)ammonium 3-carboxybenzoate
por: Guo, Yun, et al.
Publicado: (2010)

Synthesis and dynamics studies of barbituric acid derivatives as urease inhibitors
por: Barakat, Assem, et al.
Publicado: (2015)

Synthesis and Anti-Proliferative Assessment of Triazolo-Thiadiazepine and Triazolo-Thiadiazine Scaffolds
por: Boraei, Ahmed T. A., et al.
Publicado: (2019)

3-Methyl-1-benzofuran-2-carbohydrazide
por: Abdel-Aziz, Hatem A., et al.
Publicado: (2012)

(E)-3-Anilino-2-benzoyl-3-(methylsulfanyl)acrylonitrile
por: Abdel-Aziz, Hatem A., et al.
Publicado: (2012)

3-Acetyl-1,5-diphenyl-1H-pyrazole-4-carbonitrile
por: Abdel-Aziz, Hatem A., et al.
Publicado: (2012)

(1Z,2E)-N′-{2-Chloro-1-methyl-2-[2-(4-methylphenyl)hydrazin-1-ylidene]ethylidene}-4-methoxybenzohydrazide
por: Abdel-Aziz, Hatem A., et al.
Publicado: (2012)

3-Acetyl-5-phenyl-1-p-tolyl-1H-pyrazole-4-carbonitrile
por: Abdel-Aziz, Hatem A., et al.
Publicado: (2012)

1-(4-Fluorophenyl)-2-(phenylsulfonyl)ethanone
por: Abdel-Aziz, Hatem A., et al.
Publicado: (2012)

New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate
por: Bouhlel, Ahlem, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_7dhlnvi9gfis6u54k78e6dgmu6