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Secondary Metabolites from Rubiaceae Species

This study describes some characteristics of the Rubiaceae family pertaining to the occurrence and distribution of secondary metabolites in the main genera of this family. It reports the review of phytochemical studies addressing all species of Rubiaceae, published between 1990 and 2014. Iridoids, a...

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Autores principales: Martins, Daiane, Nunez, Cecilia Veronica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331836/
https://www.ncbi.nlm.nih.gov/pubmed/26205062
http://dx.doi.org/10.3390/molecules200713422
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author Martins, Daiane
Nunez, Cecilia Veronica
author_facet Martins, Daiane
Nunez, Cecilia Veronica
author_sort Martins, Daiane
collection PubMed
description This study describes some characteristics of the Rubiaceae family pertaining to the occurrence and distribution of secondary metabolites in the main genera of this family. It reports the review of phytochemical studies addressing all species of Rubiaceae, published between 1990 and 2014. Iridoids, anthraquinones, triterpenes, indole alkaloids as well as other varying alkaloid subclasses, have shown to be the most common. These compounds have been mostly isolated from the genera Uncaria, Psychotria, Hedyotis, Ophiorrhiza and Morinda. The occurrence and distribution of iridoids, alkaloids and anthraquinones point out their chemotaxonomic correlation among tribes and subfamilies. From an evolutionary point of view, Rubioideae is the most ancient subfamily, followed by Ixoroideae and finally Cinchonoideae. The chemical biosynthetic pathway, which is not so specific in Rubioideae, can explain this and large amounts of both iridoids and indole alkaloids are produced. In Ixoroideae, the most active biosysthetic pathway is the one that produces iridoids; while in Cinchonoideae, it produces indole alkaloids together with other alkaloids. The chemical biosynthetic pathway now supports this botanical conclusion.
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spelling pubmed-63318362019-01-24 Secondary Metabolites from Rubiaceae Species Martins, Daiane Nunez, Cecilia Veronica Molecules Review This study describes some characteristics of the Rubiaceae family pertaining to the occurrence and distribution of secondary metabolites in the main genera of this family. It reports the review of phytochemical studies addressing all species of Rubiaceae, published between 1990 and 2014. Iridoids, anthraquinones, triterpenes, indole alkaloids as well as other varying alkaloid subclasses, have shown to be the most common. These compounds have been mostly isolated from the genera Uncaria, Psychotria, Hedyotis, Ophiorrhiza and Morinda. The occurrence and distribution of iridoids, alkaloids and anthraquinones point out their chemotaxonomic correlation among tribes and subfamilies. From an evolutionary point of view, Rubioideae is the most ancient subfamily, followed by Ixoroideae and finally Cinchonoideae. The chemical biosynthetic pathway, which is not so specific in Rubioideae, can explain this and large amounts of both iridoids and indole alkaloids are produced. In Ixoroideae, the most active biosysthetic pathway is the one that produces iridoids; while in Cinchonoideae, it produces indole alkaloids together with other alkaloids. The chemical biosynthetic pathway now supports this botanical conclusion. MDPI 2015-07-22 /pmc/articles/PMC6331836/ /pubmed/26205062 http://dx.doi.org/10.3390/molecules200713422 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martins, Daiane
Nunez, Cecilia Veronica
Secondary Metabolites from Rubiaceae Species
title Secondary Metabolites from Rubiaceae Species
title_full Secondary Metabolites from Rubiaceae Species
title_fullStr Secondary Metabolites from Rubiaceae Species
title_full_unstemmed Secondary Metabolites from Rubiaceae Species
title_short Secondary Metabolites from Rubiaceae Species
title_sort secondary metabolites from rubiaceae species
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331836/
https://www.ncbi.nlm.nih.gov/pubmed/26205062
http://dx.doi.org/10.3390/molecules200713422
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