Efficient Diethylzinc/Gallic Acid and Diethylzinc/Gallic Acid Ester Catalytic Systems for the Ring-Opening Polymerization of rac-Lactide

Polylactide (PLA) represents one of the most promising biomedical polymers due to its biodegradability, bioresorbability and good biocompatibility. This work highlights the synthesis and characterization of PLAs using novel diethylzinc/gallic acid (ZnEt(2)/GAc) and diethylzinc/propyl gallate (ZnEt(2...

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Autores principales: Żółtowska, Karolina, Piotrowska, Urszula, Oledzka, Ewa, Sobczak, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331839/
https://www.ncbi.nlm.nih.gov/pubmed/26670224
http://dx.doi.org/10.3390/molecules201219815
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author Żółtowska, Karolina
Piotrowska, Urszula
Oledzka, Ewa
Sobczak, Marcin
author_facet Żółtowska, Karolina
Piotrowska, Urszula
Oledzka, Ewa
Sobczak, Marcin
author_sort Żółtowska, Karolina
collection PubMed
description Polylactide (PLA) represents one of the most promising biomedical polymers due to its biodegradability, bioresorbability and good biocompatibility. This work highlights the synthesis and characterization of PLAs using novel diethylzinc/gallic acid (ZnEt(2)/GAc) and diethylzinc/propyl gallate (ZnEt(2)/PGAc) catalytic systems that are safe for human body. The results of the ring-opening polymerization (ROP) of rac-lactide (rac-LA) in the presence of zinc-based catalytic systems have shown that, depending on the reaction conditions, “predominantly isotactic”, disyndiotactic or atactic PLA can be obtained. Therefore, the controlled and stereoselective ROP of rac-LA is discussed in detail in this paper.
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spelling pubmed-63318392019-01-24 Efficient Diethylzinc/Gallic Acid and Diethylzinc/Gallic Acid Ester Catalytic Systems for the Ring-Opening Polymerization of rac-Lactide Żółtowska, Karolina Piotrowska, Urszula Oledzka, Ewa Sobczak, Marcin Molecules Article Polylactide (PLA) represents one of the most promising biomedical polymers due to its biodegradability, bioresorbability and good biocompatibility. This work highlights the synthesis and characterization of PLAs using novel diethylzinc/gallic acid (ZnEt(2)/GAc) and diethylzinc/propyl gallate (ZnEt(2)/PGAc) catalytic systems that are safe for human body. The results of the ring-opening polymerization (ROP) of rac-lactide (rac-LA) in the presence of zinc-based catalytic systems have shown that, depending on the reaction conditions, “predominantly isotactic”, disyndiotactic or atactic PLA can be obtained. Therefore, the controlled and stereoselective ROP of rac-LA is discussed in detail in this paper. MDPI 2015-12-08 /pmc/articles/PMC6331839/ /pubmed/26670224 http://dx.doi.org/10.3390/molecules201219815 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Żółtowska, Karolina
Piotrowska, Urszula
Oledzka, Ewa
Sobczak, Marcin
Efficient Diethylzinc/Gallic Acid and Diethylzinc/Gallic Acid Ester Catalytic Systems for the Ring-Opening Polymerization of rac-Lactide
title Efficient Diethylzinc/Gallic Acid and Diethylzinc/Gallic Acid Ester Catalytic Systems for the Ring-Opening Polymerization of rac-Lactide
title_full Efficient Diethylzinc/Gallic Acid and Diethylzinc/Gallic Acid Ester Catalytic Systems for the Ring-Opening Polymerization of rac-Lactide
title_fullStr Efficient Diethylzinc/Gallic Acid and Diethylzinc/Gallic Acid Ester Catalytic Systems for the Ring-Opening Polymerization of rac-Lactide
title_full_unstemmed Efficient Diethylzinc/Gallic Acid and Diethylzinc/Gallic Acid Ester Catalytic Systems for the Ring-Opening Polymerization of rac-Lactide
title_short Efficient Diethylzinc/Gallic Acid and Diethylzinc/Gallic Acid Ester Catalytic Systems for the Ring-Opening Polymerization of rac-Lactide
title_sort efficient diethylzinc/gallic acid and diethylzinc/gallic acid ester catalytic systems for the ring-opening polymerization of rac-lactide
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331839/
https://www.ncbi.nlm.nih.gov/pubmed/26670224
http://dx.doi.org/10.3390/molecules201219815
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