Cargando…

Influence of Solid Drug Delivery System Formulation on Poorly Water-Soluble Drug Dissolution and Permeability

The majority of drugs have a low dissolution rate, which is a limiting step for their absorption. In this manuscript, solid dispersions (SD), solid self-microemulsifying drug delivery systems (S-SMEDDS) and solid self-nanoemulsifying drug delivery systems (S-SNEDDS) were evaluated as potential formu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krstić, Marko, Popović, Miljana, Dobričić, Vladimir, Ibrić, Svetlana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331904/ https://www.ncbi.nlm.nih.gov/pubmed/26287134 http://dx.doi.org/10.3390/molecules200814684

Ejemplares similares

Surface Dissolution UV Imaging for Investigation of Dissolution of Poorly Soluble Drugs and Their Amorphous Formulation
por: Long, Chiau Ming, et al.
Publicado: (2019)

Development of ternary solid dispersions with hydrophilic polymer and surface adsorbent for improving dissolution rate of carbamazepine
por: Vojinović, Tanja, et al.
Publicado: (2018)

Electrospun nanofibers: A nanotechnological approach for drug delivery and dissolution optimization in poorly water-soluble drugs
por: Castillo-Henríquez, Luis, et al.
Publicado: (2020)

Improvement of In Vitro Dissolution of the Poor Water-Soluble Amlodipine Drug by Solid Dispersion with Irradiated Polyvinylpyrrolidone
por: Ghobashy, Mohamed Mohamady, et al.
Publicado: (2020)

Effects of Polymers on the Drug Solubility and Dissolution Enhancement of Poorly Water-Soluble Rivaroxaban
por: Choi, Min-Jong, et al.
Publicado: (2022)

Multicomponent cyclodextrin system for improvement of solubility and dissolution rate of poorly water soluble drug()
por: Patel, Mayank, et al.
Publicado: (2019)

Analytical and Computational Methods for the Estimation of Drug-Polymer Solubility and Miscibility in Solid Dispersions Development
por: Medarević, Djordje, et al.
Publicado: (2019)

Pharmaceutical Dispersion Techniques for Dissolution and Bioavailability Enhancement of Poorly Water-Soluble Drugs
por: Zhang, Xingwang, et al.
Publicado: (2018)

Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium
por: Sathisaran, Indumathi, et al.
Publicado: (2018)

Design, optimization and evaluation of glipizide solid self-nanoemulsifying drug delivery for enhanced solubility and dissolution
por: Dash, Rajendra Narayan, et al.
Publicado: (2015)

Improvement in solubility of poor water-soluble drugs by solid dispersion
por: Sareen, Swati, et al.
Publicado: (2012)

Formulation of Orally Disintegrating Films as an Amorphous Solid Solution of a Poorly Water-Soluble Drug
por: Panraksa, Pattaraporn, et al.
Publicado: (2020)

In vivo dissolution of poorly water-soluble drugs: Proof of concept based on fluorescence bioimaging
por: Yang, Yinqian, et al.
Publicado: (2021)

Evaluation of Poorly Soluble Drugs’ Dissolution Rate by Laser Scattering in Different Water Isotopologues
por: Uspenskaya, Elena V., et al.
Publicado: (2021)

Solid formulation of a supersaturable self-microemulsifying drug delivery system for valsartan with improved dissolution and bioavailability
por: Yeom, Dong Woo, et al.
Publicado: (2017)

Multi-Compartmental Dissolution Method, an Efficient Tool for the Development of Enhanced Bioavailability Formulations Containing Poorly Soluble Acidic Drugs
por: Katona, Miklós Tamás, et al.
Publicado: (2023)

Enhanced dissolution of poorly soluble antiviral drugs from nanoparticles of cellulose acetate based solid dispersion matrices
por: Mazumder, Sonal, et al.
Publicado: (2017)

Combination of co-crystal and nanocrystal techniques to improve the solubility and dissolution rate of poorly soluble drugs
por: Huang, Zun, et al.
Publicado: (2022)

Positively Charged Nanostructured Lipid Carriers and Their Effect on the Dissolution of Poorly Soluble Drugs
por: Choi, Kyeong-Ok, et al.
Publicado: (2016)

The Impact of Process and Formulation Parameters on the Fabrication of Efavirenz Nanosuspension to Improve Drug Solubility and Dissolution
por: Rashed, Mahtab, et al.
Publicado: (2022)

Hydrogel-Based Drug Delivery Systems for Poorly Water-Soluble Drugs
por: McKenzie, Matthew, et al.
Publicado: (2015)

Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs
por: Tran, Thao T. D., et al.
Publicado: (2020)

Smartcrystals for Efficient Dissolution of Poorly Water-Soluble Meloxicam
por: Ambrus, Rita, et al.
Publicado: (2022)

Preparation of Solid Self-Nanoemulsifying Drug Delivery Systems (S-SNEDDS) by Co-Extrusion of Liquid SNEDDS and Polymeric Carriers—A New and Promising Formulation Approach to Improve the Solubility of Poorly Water-Soluble Drugs
por: Schmied, Fabian-Pascal, et al.
Publicado: (2022)

In-situ freeze-drying - forming amorphous solids directly within capsules: An investigation of dissolution enhancement for a poorly soluble drug
por: Alqurshi, Abdulmalik, et al.
Publicado: (2017)

Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media
por: Teleki, Alexandra, et al.
Publicado: (2020)

The Effect of the Particle Size Reduction on the Biorelevant Solubility and Dissolution of Poorly Soluble Drugs with Different Acid-Base Character
por: Csicsák, Dóra, et al.
Publicado: (2023)

Editor Profiles: Guest Editors of Special Issue on Enhancement of Dissolution and Oral Bioavailability of Poorly Water-soluble Drugs
por: Wu, Wei, et al.
Publicado: (2019)

The Self-Assembly Phenomenon of Poloxamers and Its Effect on the Dissolution of a Poorly Soluble Drug from Solid Dispersions Obtained by Solvent Methods
por: Szafraniec, Joanna, et al.
Publicado: (2019)

Development of orally disintegrating tablets containing solid dispersion of a poorly soluble drug for enhanced dissolution: In-vitro optimization/in-vivo evaluation
por: Fouad, Shahinaze A., et al.
Publicado: (2020)

Impact of gastrointestinal differences in veterinary species on the oral drug solubility, in vivo dissolution, and formulation of veterinary therapeutics ()
por: Martinez, Marilyn N., et al.
Publicado: (2022)

Dose-Dependent Solubility–Permeability Interplay for Poorly Soluble Drugs under Non-Sink Conditions
por: Sugita, Kazuya, et al.
Publicado: (2021)

Potential of solid dispersions to enhance solubility, bioavailability, and therapeutic efficacy of poorly water-soluble drugs: newer formulation techniques, current marketed scenario and patents
por: Alshehri, Sultan, et al.
Publicado: (2020)

Oral Delivery of Lipophilic Drugs: The Tradeoff between Solubility Increase and Permeability Decrease When Using Cyclodextrin-Based Formulations
por: Beig, Avital, et al.
Publicado: (2013)

Overview of the Manufacturing Methods of Solid Dispersion Technology for Improving the Solubility of Poorly Water-Soluble Drugs and Application to Anticancer Drugs
por: Tran, Phuong, et al.
Publicado: (2019)

Embedding of Poorly Water-Soluble Drugs in Orodispersible Films—Comparison of Five Formulation Strategies
por: Steiner, Denise, et al.
Publicado: (2022)

Polyaphron Formulations Stabilised with Different Water-Soluble Polymers for Ocular Drug Delivery
por: Moiseev, Roman V., et al.
Publicado: (2022)

Insoluble Polymers in Solid Dispersions for Improving Bioavailability of Poorly Water-Soluble Drugs
por: Tran, Thao T.D., et al.
Publicado: (2020)

Self nanoemulsifying drug delivery system of stabilized ellagic acid–phospholipid complex with improved dissolution and permeability
por: Avachat, Amelia M., et al.
Publicado: (2015)

Cheminformatics-driven discovery of polymeric micelle formulations for poorly soluble drugs
por: Alves, Vinicius M., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_sr8k6eajq30eap4a9a8rj2g8v7