Cargando…

RNA Aptamers as Molecular Tools to Study the Functionality of the Hepatitis C Virus CRE Region

Background: Hepatitis C virus (HCV) contains a (+) ssRNA genome with highly conserved structural, functional RNA domains, many of them with unknown roles for the consecution of the viral cycle. Such genomic domains are candidate therapeutic targets. This study reports the functional characterization...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fernández-Sanlés, Alba, Berzal-Herranz, Beatriz, González-Matamala, Rodrigo, Ríos-Marco, Pablo, Romero-López, Cristina, Berzal-Herranz, Alfredo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331917/ https://www.ncbi.nlm.nih.gov/pubmed/26364632 http://dx.doi.org/10.3390/molecules200916030

Ejemplares similares

Functional Information Stored in the Conserved Structural RNA Domains of Flavivirus Genomes
por: Fernández-Sanlés, Alba, et al.
Publicado: (2017)

Two Examples of RNA Aptamers with Antiviral Activity. Are Aptamers the Wished Antiviral Drugs?
por: Berzal-Herranz, Alfredo, et al.
Publicado: (2020)

Aptamers: Biomedical Interest and Applications
por: Romero-López, Cristina, et al.
Publicado: (2017)

The HCV genome domains 5BSL3.1 and 5BSL3.3 act as managers of translation
por: Romero-López, Cristina, et al.
Publicado: (2018)

The chaperone-like activity of the hepatitis C virus IRES and CRE elements regulates genome dimerization
por: Romero-López, Cristina, et al.
Publicado: (2017)

The 5BSL3.2 Functional RNA Domain Connects Distant Regions in the Hepatitis C Virus Genome
por: Romero-López, Cristina, et al.
Publicado: (2017)

Anti-HCV RNA Aptamers Targeting the Genomic cis-Acting Replication Element
por: Marton, Soledad, et al.
Publicado: (2011)

The cis-acting replication element of the Hepatitis C virus genome recruits host factors that influence viral replication and translation
por: Ríos-Marco, Pablo, et al.
Publicado: (2016)

Development of Optimized Inhibitor RNAs Allowing Multisite-Targeting of the HCV Genome
por: Romero-López, Cristina, et al.
Publicado: (2017)

Potential of the Other Genetic Information Coded by the Viral RNA Genomes as Antiviral Target
por: Berzal-Herranz, Alfredo, et al.
Publicado: (2019)

The Role of the RNA-RNA Interactome in the Hepatitis C Virus Life Cycle
por: Romero-López, Cristina, et al.
Publicado: (2020)

The Genomic 3′ UTR of Flaviviruses Is a Translation Initiation Enhancer
por: Berzal-Herranz, Alfredo, et al.
Publicado: (2022)

Structure and function analysis of the essential 3′X domain of hepatitis C virus
por: Castillo-Martínez, Jesús, et al.
Publicado: (2020)

Inter- and Intramolecular RNA–RNA Interactions Modulate the Regulation of Translation Mediated by the 3′ UTR in West Nile Virus
por: Romero-López, Cristina, et al.
Publicado: (2023)

End-to-end crosstalk within the hepatitis C virus genome mediates the conformational switch of the 3′X-tail region
por: Romero-López, Cristina, et al.
Publicado: (2014)

Information Encoded by the Flavivirus Genomes beyond the Nucleotide Sequence
por: Ramos-Lorente, Sara, et al.
Publicado: (2021)

In Vitro Methods to Decipher the Structure of Viral RNA Genomes
por: Romero-López, Cristina, et al.
Publicado: (2021)

The folding of the hepatitis C virus internal ribosome entry site depends on the 3′-end of the viral genome
por: Romero-López, Cristina, et al.
Publicado: (2012)

Efficient HIV-1 inhibition by a 16 nt-long RNA aptamer designed by combining in vitro selection and in silico optimisation strategies
por: Sánchez-Luque, Francisco J., et al.
Publicado: (2014)

The 5′-tail of antisense RNAII of pMV158 plays a critical role in binding to the target mRNA and in translation inhibition of repB
por: López-Aguilar, Celeste, et al.
Publicado: (2015)

CriTER-A: A Novel Temperature-Dependent Noncoding RNA Switch in the Telomeric Transcriptome of Chironomus riparius
por: Romero-López, Cristina, et al.
Publicado: (2021)

OBITUARY
por: Wagner, Gerhart, et al.
Publicado: (2005)

In Vitro and Ex Vivo Selection Procedures for Identifying Potentially Therapeutic DNA and RNA Molecules
por: Marton, Soledad, et al.
Publicado: (2010)

Inhibition of HIV-1 Replication and Dimerization Interference by Dual Inhibitory RNAs
por: Sánchez-Luque, Francisco J., et al.
Publicado: (2010)

A Dual Interaction Between the 5′- and 3′-Ends of the Melon Necrotic Spot Virus (MNSV) RNA Genome Is Required for Efficient Cap-Independent Translation
por: Miras, Manuel, et al.
Publicado: (2018)

Netrin-1 Protects Hepatocytes Against Cell Death Through Sustained Translation During the Unfolded Protein Response
por: Lahlali, Thomas, et al.
Publicado: (2016)

RNA self-cleavage activated by ultraviolet light-induced oxidation
por: Ariza-Mateos, Ascensión, et al.
Publicado: (2012)

Cannabinoid Drugs-Related Neuroprotection as a Potential Therapeutic Tool Against Chemotherapy-Induced Cognitive Impairment
por: Boullon, Laura, et al.
Publicado: (2021)

Could inhibition of metalloproteinases be used to block the process of metastasis?
por: Alba, Jesús, et al.
Publicado: (2022)

Optimising the zebrafish Cre/Lox toolbox. Codon improved iCre, new gateway tools, Cre protein and guidelines
por: Tromp, Alisha, et al.
Publicado: (2023)

Aptamers as Theragnostic Tools in Prostate Cancer
por: Cruz-Hernández, Carlos David, et al.
Publicado: (2022)

Sex Differences in a Rat Model of Peripheral Neuropathic Pain and Associated Levels of Endogenous Cannabinoid Ligands
por: Boullon, Laura, et al.
Publicado: (2021)

iSuRe-Cre is a genetic tool to reliably induce and report Cre-dependent genetic modifications
por: Fernández-Chacón, Macarena, et al.
Publicado: (2019)

Glycosylation of matrix metalloproteases and tissue inhibitors: present state, challenges and opportunities
por: Boon, Lise, et al.
Publicado: (2016)

Use of Aptamers as Diagnostics Tools and Antiviral Agents for Human Viruses
por: González, Víctor M., et al.
Publicado: (2016)

Bordetella hinzii Endocarditis, A Clinical Case Not Previously Described
por: González, María Mateos, et al.
Publicado: (2019)

Demand generation and social mobilisation for integrated community case management (iCCM) and child health: Lessons learned from successful programmes in Niger and Mozambique
por: Sharkey, Alyssa B, et al.
Publicado: (2014)

Aptamers as Diagnostic Tools in Cancer
por: Ruiz Ciancio, Dario, et al.
Publicado: (2018)

QRS duration: a novel marker of microvascular reperfusion as assessed by myocardial blush grade in ST elevation myocardial infarction patients undergoing a primary percutaneous intervention
por: Karahan, Zülküf, et al.
Publicado: (2015)

Conditional Transgenesis Using Dimerizable Cre (DiCre)
por: Jullien, Nicolas, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_jfbvvd9te9ulnmgf1o78v6lovq