Bioactive Cembranoids from the South China Sea Soft Coral Sarcophyton elegans

Four new cembranoids, sarcophelegans A–D (1–4) and six known analogues (5–10) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were elucidated through detailed spectroscopic analysis, and the absolute configuration of 1 was confirmed by single-crystal X-ray dif...

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Detalles Bibliográficos
Autores principales: Liu, Xin, Zhang, Junsheng, Liu, Qiao, Tang, Guihua, Wang, Hongsheng, Fan, Chengqi, Yin, Sheng, Beutler, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331945/
https://www.ncbi.nlm.nih.gov/pubmed/26205057
http://dx.doi.org/10.3390/molecules200713324
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author Liu, Xin
Zhang, Junsheng
Liu, Qiao
Tang, Guihua
Wang, Hongsheng
Fan, Chengqi
Yin, Sheng
Beutler, John
author_facet Liu, Xin
Zhang, Junsheng
Liu, Qiao
Tang, Guihua
Wang, Hongsheng
Fan, Chengqi
Yin, Sheng
Beutler, John
author_sort Liu, Xin
collection PubMed
description Four new cembranoids, sarcophelegans A–D (1–4) and six known analogues (5–10) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were elucidated through detailed spectroscopic analysis, and the absolute configuration of 1 was confirmed by single-crystal X-ray diffraction. The antimigratory potential of compounds 1–10 were evaluated and compounds 2 and 6 were found to inhibit human breast tumor MDA-MB-231 cell migration at 10 μM.
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spelling pubmed-63319452019-01-24 Bioactive Cembranoids from the South China Sea Soft Coral Sarcophyton elegans Liu, Xin Zhang, Junsheng Liu, Qiao Tang, Guihua Wang, Hongsheng Fan, Chengqi Yin, Sheng Beutler, John Molecules Article Four new cembranoids, sarcophelegans A–D (1–4) and six known analogues (5–10) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were elucidated through detailed spectroscopic analysis, and the absolute configuration of 1 was confirmed by single-crystal X-ray diffraction. The antimigratory potential of compounds 1–10 were evaluated and compounds 2 and 6 were found to inhibit human breast tumor MDA-MB-231 cell migration at 10 μM. MDPI 2015-07-22 /pmc/articles/PMC6331945/ /pubmed/26205057 http://dx.doi.org/10.3390/molecules200713324 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Xin
Zhang, Junsheng
Liu, Qiao
Tang, Guihua
Wang, Hongsheng
Fan, Chengqi
Yin, Sheng
Beutler, John
Bioactive Cembranoids from the South China Sea Soft Coral Sarcophyton elegans
title Bioactive Cembranoids from the South China Sea Soft Coral Sarcophyton elegans
title_full Bioactive Cembranoids from the South China Sea Soft Coral Sarcophyton elegans
title_fullStr Bioactive Cembranoids from the South China Sea Soft Coral Sarcophyton elegans
title_full_unstemmed Bioactive Cembranoids from the South China Sea Soft Coral Sarcophyton elegans
title_short Bioactive Cembranoids from the South China Sea Soft Coral Sarcophyton elegans
title_sort bioactive cembranoids from the south china sea soft coral sarcophyton elegans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331945/
https://www.ncbi.nlm.nih.gov/pubmed/26205057
http://dx.doi.org/10.3390/molecules200713324
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