Cargando…

The Effect of Low Monotonic Doses of Zearalenone on Selected Reproductive Tissues in Pre-Pubertal Female Dogs—A Review

The growing interest in toxic substances combined with advancements in biological sciences has shed a new light on the problem of mycotoxins contaminating feeds and foods. An interdisciplinary approach was developed by identifying dose-response relationships in key research concepts, including the l...

Descripción completa

Detalles Bibliográficos
Autores principales: Gajęcka, Magdalena, Zielonka, Łukasz, Gajęcki, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331970/
https://www.ncbi.nlm.nih.gov/pubmed/26610443
http://dx.doi.org/10.3390/molecules201119726
_version_ 1783387240182841344
author Gajęcka, Magdalena
Zielonka, Łukasz
Gajęcki, Maciej
author_facet Gajęcka, Magdalena
Zielonka, Łukasz
Gajęcki, Maciej
author_sort Gajęcka, Magdalena
collection PubMed
description The growing interest in toxic substances combined with advancements in biological sciences has shed a new light on the problem of mycotoxins contaminating feeds and foods. An interdisciplinary approach was developed by identifying dose-response relationships in key research concepts, including the low dose theory of estrogen-like compounds, hormesis, NOAEL dose, compensatory response and/or food tolerance, and effects of exposure to undesirable substances. The above considerations increased the researchers’ interest in risk evaluation, namely: (i) clinical symptoms associated with long-term, daily exposure to low doses of a toxic compound; and (ii) dysfunctions at cellular or tissue level that do not produce clinical symptoms. Research advancements facilitate the extrapolation of results and promote the use of novel tools for evaluating the risk of exposure, for example exposure to zearalenone in pre-pubertal female dogs. The arguments presented in this paper suggest that low doses of zearalenone in commercial feeds stimulate metabolic processes and increase weight gains. Those processes are accompanied by lower proliferation rates in the ovaries, neoangiogenesis and vasodilation in the ovaries and the uterus, changes in the steroid hormone profile, and changes in the activity of hydroxysteroid dehydrogenases. All of the above changes result from exogenous hyperestrogenizm.
format Online
Article
Text
id pubmed-6331970
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-63319702019-01-24 The Effect of Low Monotonic Doses of Zearalenone on Selected Reproductive Tissues in Pre-Pubertal Female Dogs—A Review Gajęcka, Magdalena Zielonka, Łukasz Gajęcki, Maciej Molecules Review The growing interest in toxic substances combined with advancements in biological sciences has shed a new light on the problem of mycotoxins contaminating feeds and foods. An interdisciplinary approach was developed by identifying dose-response relationships in key research concepts, including the low dose theory of estrogen-like compounds, hormesis, NOAEL dose, compensatory response and/or food tolerance, and effects of exposure to undesirable substances. The above considerations increased the researchers’ interest in risk evaluation, namely: (i) clinical symptoms associated with long-term, daily exposure to low doses of a toxic compound; and (ii) dysfunctions at cellular or tissue level that do not produce clinical symptoms. Research advancements facilitate the extrapolation of results and promote the use of novel tools for evaluating the risk of exposure, for example exposure to zearalenone in pre-pubertal female dogs. The arguments presented in this paper suggest that low doses of zearalenone in commercial feeds stimulate metabolic processes and increase weight gains. Those processes are accompanied by lower proliferation rates in the ovaries, neoangiogenesis and vasodilation in the ovaries and the uterus, changes in the steroid hormone profile, and changes in the activity of hydroxysteroid dehydrogenases. All of the above changes result from exogenous hyperestrogenizm. MDPI 2015-11-19 /pmc/articles/PMC6331970/ /pubmed/26610443 http://dx.doi.org/10.3390/molecules201119726 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gajęcka, Magdalena
Zielonka, Łukasz
Gajęcki, Maciej
The Effect of Low Monotonic Doses of Zearalenone on Selected Reproductive Tissues in Pre-Pubertal Female Dogs—A Review
title The Effect of Low Monotonic Doses of Zearalenone on Selected Reproductive Tissues in Pre-Pubertal Female Dogs—A Review
title_full The Effect of Low Monotonic Doses of Zearalenone on Selected Reproductive Tissues in Pre-Pubertal Female Dogs—A Review
title_fullStr The Effect of Low Monotonic Doses of Zearalenone on Selected Reproductive Tissues in Pre-Pubertal Female Dogs—A Review
title_full_unstemmed The Effect of Low Monotonic Doses of Zearalenone on Selected Reproductive Tissues in Pre-Pubertal Female Dogs—A Review
title_short The Effect of Low Monotonic Doses of Zearalenone on Selected Reproductive Tissues in Pre-Pubertal Female Dogs—A Review
title_sort effect of low monotonic doses of zearalenone on selected reproductive tissues in pre-pubertal female dogs—a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331970/
https://www.ncbi.nlm.nih.gov/pubmed/26610443
http://dx.doi.org/10.3390/molecules201119726
work_keys_str_mv AT gajeckamagdalena theeffectoflowmonotonicdosesofzearalenoneonselectedreproductivetissuesinprepubertalfemaledogsareview
AT zielonkałukasz theeffectoflowmonotonicdosesofzearalenoneonselectedreproductivetissuesinprepubertalfemaledogsareview
AT gajeckimaciej theeffectoflowmonotonicdosesofzearalenoneonselectedreproductivetissuesinprepubertalfemaledogsareview
AT gajeckamagdalena effectoflowmonotonicdosesofzearalenoneonselectedreproductivetissuesinprepubertalfemaledogsareview
AT zielonkałukasz effectoflowmonotonicdosesofzearalenoneonselectedreproductivetissuesinprepubertalfemaledogsareview
AT gajeckimaciej effectoflowmonotonicdosesofzearalenoneonselectedreproductivetissuesinprepubertalfemaledogsareview