Quaternary Alkylammonium Conjugates of Steroids: Synthesis, Molecular Structure, and Biological Studies

The methods of synthesis as well as physical, spectroscopic ((1)H-NMR, (13)C-NMR, and FT-IR, ESI-MS), and biological properties of quaternary and dimeric quaternary alkylammonium conjugates of steroids are presented. The results were contrasted with theoretical calculations (PM5 methods) and potenti...

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Detalles Bibliográficos
Autores principales: Brycki, Bogumił, Koenig, Hanna, Pospieszny, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331993/
https://www.ncbi.nlm.nih.gov/pubmed/26610455
http://dx.doi.org/10.3390/molecules201119735
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author Brycki, Bogumił
Koenig, Hanna
Pospieszny, Tomasz
author_facet Brycki, Bogumił
Koenig, Hanna
Pospieszny, Tomasz
author_sort Brycki, Bogumił
collection PubMed
description The methods of synthesis as well as physical, spectroscopic ((1)H-NMR, (13)C-NMR, and FT-IR, ESI-MS), and biological properties of quaternary and dimeric quaternary alkylammonium conjugates of steroids are presented. The results were contrasted with theoretical calculations (PM5 methods) and potential pharmacological properties (PASS). Alkylammonium sterols exhibit a broad spectrum of antimicrobial activity comparable to squalamine.
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spelling pubmed-63319932019-01-24 Quaternary Alkylammonium Conjugates of Steroids: Synthesis, Molecular Structure, and Biological Studies Brycki, Bogumił Koenig, Hanna Pospieszny, Tomasz Molecules Review The methods of synthesis as well as physical, spectroscopic ((1)H-NMR, (13)C-NMR, and FT-IR, ESI-MS), and biological properties of quaternary and dimeric quaternary alkylammonium conjugates of steroids are presented. The results were contrasted with theoretical calculations (PM5 methods) and potential pharmacological properties (PASS). Alkylammonium sterols exhibit a broad spectrum of antimicrobial activity comparable to squalamine. MDPI 2015-11-23 /pmc/articles/PMC6331993/ /pubmed/26610455 http://dx.doi.org/10.3390/molecules201119735 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Brycki, Bogumił
Koenig, Hanna
Pospieszny, Tomasz
Quaternary Alkylammonium Conjugates of Steroids: Synthesis, Molecular Structure, and Biological Studies
title Quaternary Alkylammonium Conjugates of Steroids: Synthesis, Molecular Structure, and Biological Studies
title_full Quaternary Alkylammonium Conjugates of Steroids: Synthesis, Molecular Structure, and Biological Studies
title_fullStr Quaternary Alkylammonium Conjugates of Steroids: Synthesis, Molecular Structure, and Biological Studies
title_full_unstemmed Quaternary Alkylammonium Conjugates of Steroids: Synthesis, Molecular Structure, and Biological Studies
title_short Quaternary Alkylammonium Conjugates of Steroids: Synthesis, Molecular Structure, and Biological Studies
title_sort quaternary alkylammonium conjugates of steroids: synthesis, molecular structure, and biological studies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331993/
https://www.ncbi.nlm.nih.gov/pubmed/26610455
http://dx.doi.org/10.3390/molecules201119735
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AT koenighanna quaternaryalkylammoniumconjugatesofsteroidssynthesismolecularstructureandbiologicalstudies
AT pospiesznytomasz quaternaryalkylammoniumconjugatesofsteroidssynthesismolecularstructureandbiologicalstudies

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