A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa

A new ionone glycoside, frehmaglutoside I (1), and three new rhemaneolignans A–C (2–4) were isolated from the 95% EtOH extract of the roots of Rehmannia glutinosa. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these compounds we...

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Autores principales: Li, Meng, Wang, Xiaolan, Zheng, Xiaoke, Wang, Jianchao, Zhao, Wei, Song, Kai, Zhao, Xuan, Zhang, Yanli, Kuang, Haixue, Feng, Weisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332001/
https://www.ncbi.nlm.nih.gov/pubmed/26307955
http://dx.doi.org/10.3390/molecules200815192
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author Li, Meng
Wang, Xiaolan
Zheng, Xiaoke
Wang, Jianchao
Zhao, Wei
Song, Kai
Zhao, Xuan
Zhang, Yanli
Kuang, Haixue
Feng, Weisheng
author_facet Li, Meng
Wang, Xiaolan
Zheng, Xiaoke
Wang, Jianchao
Zhao, Wei
Song, Kai
Zhao, Xuan
Zhang, Yanli
Kuang, Haixue
Feng, Weisheng
author_sort Li, Meng
collection PubMed
description A new ionone glycoside, frehmaglutoside I (1), and three new rhemaneolignans A–C (2–4) were isolated from the 95% EtOH extract of the roots of Rehmannia glutinosa. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these compounds were evaluated for their protective effects on cardiocytes impaired by doxorubicin in H9c2 cells. Among them, compounds 1–3 exhibited protective effects against DOX-induced cardiotoxicity.
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spelling pubmed-63320012019-01-24 A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa Li, Meng Wang, Xiaolan Zheng, Xiaoke Wang, Jianchao Zhao, Wei Song, Kai Zhao, Xuan Zhang, Yanli Kuang, Haixue Feng, Weisheng Molecules Article A new ionone glycoside, frehmaglutoside I (1), and three new rhemaneolignans A–C (2–4) were isolated from the 95% EtOH extract of the roots of Rehmannia glutinosa. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these compounds were evaluated for their protective effects on cardiocytes impaired by doxorubicin in H9c2 cells. Among them, compounds 1–3 exhibited protective effects against DOX-induced cardiotoxicity. MDPI 2015-08-20 /pmc/articles/PMC6332001/ /pubmed/26307955 http://dx.doi.org/10.3390/molecules200815192 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Meng
Wang, Xiaolan
Zheng, Xiaoke
Wang, Jianchao
Zhao, Wei
Song, Kai
Zhao, Xuan
Zhang, Yanli
Kuang, Haixue
Feng, Weisheng
A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa
title A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa
title_full A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa
title_fullStr A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa
title_full_unstemmed A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa
title_short A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa
title_sort new ionone glycoside and three new rhemaneolignans from the roots of rehmannia glutinosa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332001/
https://www.ncbi.nlm.nih.gov/pubmed/26307955
http://dx.doi.org/10.3390/molecules200815192
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