Design, Synthesis, Activity and Docking Study of Sorafenib Analogs Bearing Sulfonylurea Unit

Two series of novel sorafenib analogs containing a sulfonylurea unit were synthesized and their chemical structures were confirmed by (1)H-NMR, (1)(3)C-NMR, MS spectrum and elemental analysis. The synthesized compounds were evaluated for the cytotoxicity against A549, Hela, MCF-7, and PC-3 cancer ce...

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Detalles Bibliográficos
Autores principales: Wu, Chunjiang, Wang, Min, Tang, Qidong, Luo, Rong, Chen, Le, Zheng, Pengwu, Zhu, Wufu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332012/
https://www.ncbi.nlm.nih.gov/pubmed/26512636
http://dx.doi.org/10.3390/molecules201019361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332012/
https://www.ncbi.nlm.nih.gov/pubmed/26512636
http://dx.doi.org/10.3390/molecules201019361

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