Identification of Minor Benzoylated 4-Phenylcoumarins from a Mammea neurophylla Bark Extract

Through dereplication analysis, seven known Mammea coumarins were identified in a fraction obtained from Mammea neurophylla dichloromethane bark extract selected for its ability to prevent advanced glycation end-product (AGE) formation. Among them, a careful examination of the NMR dataset of pedilan...

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Autores principales: Dang, Bach Tai, Rouger, Caroline, Litaudon, Marc, Richomme, Pascal, Séraphin, Denis, Derbré, Séverine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332034/
https://www.ncbi.nlm.nih.gov/pubmed/26404214
http://dx.doi.org/10.3390/molecules201017735
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author Dang, Bach Tai
Rouger, Caroline
Litaudon, Marc
Richomme, Pascal
Séraphin, Denis
Derbré, Séverine
author_facet Dang, Bach Tai
Rouger, Caroline
Litaudon, Marc
Richomme, Pascal
Séraphin, Denis
Derbré, Séverine
author_sort Dang, Bach Tai
collection PubMed
description Through dereplication analysis, seven known Mammea coumarins were identified in a fraction obtained from Mammea neurophylla dichloromethane bark extract selected for its ability to prevent advanced glycation end-product (AGE) formation. Among them, a careful examination of the NMR dataset of pedilanthocoumarin B led to a structural revision. Inspection of LC-DAD-MS(n) chromatograms allowed us to predict the presence of four new compounds, which were further isolated. Using spectroscopic methods ((1)H-, (13)C- and 2D-NMR, HRMS, UV), these compounds were identified as new benzoyl substituted 4-phenylcoumarins (iso-pedilanthocoumarin B and neurophyllol C) and 4-(1-acetoxypropyl)coumarins cyclo F (ochrocarpins H and I).
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spelling pubmed-63320342019-01-24 Identification of Minor Benzoylated 4-Phenylcoumarins from a Mammea neurophylla Bark Extract Dang, Bach Tai Rouger, Caroline Litaudon, Marc Richomme, Pascal Séraphin, Denis Derbré, Séverine Molecules Communication Through dereplication analysis, seven known Mammea coumarins were identified in a fraction obtained from Mammea neurophylla dichloromethane bark extract selected for its ability to prevent advanced glycation end-product (AGE) formation. Among them, a careful examination of the NMR dataset of pedilanthocoumarin B led to a structural revision. Inspection of LC-DAD-MS(n) chromatograms allowed us to predict the presence of four new compounds, which were further isolated. Using spectroscopic methods ((1)H-, (13)C- and 2D-NMR, HRMS, UV), these compounds were identified as new benzoyl substituted 4-phenylcoumarins (iso-pedilanthocoumarin B and neurophyllol C) and 4-(1-acetoxypropyl)coumarins cyclo F (ochrocarpins H and I). MDPI 2015-09-25 /pmc/articles/PMC6332034/ /pubmed/26404214 http://dx.doi.org/10.3390/molecules201017735 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Dang, Bach Tai
Rouger, Caroline
Litaudon, Marc
Richomme, Pascal
Séraphin, Denis
Derbré, Séverine
Identification of Minor Benzoylated 4-Phenylcoumarins from a Mammea neurophylla Bark Extract
title Identification of Minor Benzoylated 4-Phenylcoumarins from a Mammea neurophylla Bark Extract
title_full Identification of Minor Benzoylated 4-Phenylcoumarins from a Mammea neurophylla Bark Extract
title_fullStr Identification of Minor Benzoylated 4-Phenylcoumarins from a Mammea neurophylla Bark Extract
title_full_unstemmed Identification of Minor Benzoylated 4-Phenylcoumarins from a Mammea neurophylla Bark Extract
title_short Identification of Minor Benzoylated 4-Phenylcoumarins from a Mammea neurophylla Bark Extract
title_sort identification of minor benzoylated 4-phenylcoumarins from a mammea neurophylla bark extract
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332034/
https://www.ncbi.nlm.nih.gov/pubmed/26404214
http://dx.doi.org/10.3390/molecules201017735
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