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Synthesis and Evaluation of New Podophyllotoxin Derivatives with in Vitro Anticancer Activity
A series of novel podophyllotoxin derivatives were designed and synthesized. The cytotoxic activities of these compounds were tested against three tumor cell lines (HeLa, K562, and K562/A02). Most of the derivatives (IC(50) = 1–20 μM) were found to have stronger cell growth inhibitory activity than...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332074/ https://www.ncbi.nlm.nih.gov/pubmed/26154885 http://dx.doi.org/10.3390/molecules200712266 |