Anti-Inflammatory Activity of Heterocarpin from the Salt Marsh Plant Corydalis heterocarpa in LPS-Induced RAW 264.7 Macrophage Cells

The inhibitory effect of three chromones 1–3 and two coumarins 4–5 on the production of nitric oxide (NO) was evaluated in LPS-induced RAW 264.7 macrophage cells. Among the compounds tested heterocarpin (1), a furochromone, significantly inhibited its production in a dose-dependent manner. In additi...

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Autores principales: Kim, You Ah, Kong, Chang-Suk, Park, Hyo Hyun, Lee, Eunkyung, Jang, Mi-Soon, Nam, Ki-Ho, Seo, Youngwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332082/
https://www.ncbi.nlm.nih.gov/pubmed/26266403
http://dx.doi.org/10.3390/molecules200814474
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author Kim, You Ah
Kong, Chang-Suk
Park, Hyo Hyun
Lee, Eunkyung
Jang, Mi-Soon
Nam, Ki-Ho
Seo, Youngwan
author_facet Kim, You Ah
Kong, Chang-Suk
Park, Hyo Hyun
Lee, Eunkyung
Jang, Mi-Soon
Nam, Ki-Ho
Seo, Youngwan
author_sort Kim, You Ah
collection PubMed
description The inhibitory effect of three chromones 1–3 and two coumarins 4–5 on the production of nitric oxide (NO) was evaluated in LPS-induced RAW 264.7 macrophage cells. Among the compounds tested heterocarpin (1), a furochromone, significantly inhibited its production in a dose-dependent manner. In addition, heterocarpin suppressed prostaglandin E(2) (PGE(2)) production and expression of cytokines such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6).
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spelling pubmed-63320822019-01-24 Anti-Inflammatory Activity of Heterocarpin from the Salt Marsh Plant Corydalis heterocarpa in LPS-Induced RAW 264.7 Macrophage Cells Kim, You Ah Kong, Chang-Suk Park, Hyo Hyun Lee, Eunkyung Jang, Mi-Soon Nam, Ki-Ho Seo, Youngwan Molecules Article The inhibitory effect of three chromones 1–3 and two coumarins 4–5 on the production of nitric oxide (NO) was evaluated in LPS-induced RAW 264.7 macrophage cells. Among the compounds tested heterocarpin (1), a furochromone, significantly inhibited its production in a dose-dependent manner. In addition, heterocarpin suppressed prostaglandin E(2) (PGE(2)) production and expression of cytokines such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6). MDPI 2015-08-10 /pmc/articles/PMC6332082/ /pubmed/26266403 http://dx.doi.org/10.3390/molecules200814474 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, You Ah
Kong, Chang-Suk
Park, Hyo Hyun
Lee, Eunkyung
Jang, Mi-Soon
Nam, Ki-Ho
Seo, Youngwan
Anti-Inflammatory Activity of Heterocarpin from the Salt Marsh Plant Corydalis heterocarpa in LPS-Induced RAW 264.7 Macrophage Cells
title Anti-Inflammatory Activity of Heterocarpin from the Salt Marsh Plant Corydalis heterocarpa in LPS-Induced RAW 264.7 Macrophage Cells
title_full Anti-Inflammatory Activity of Heterocarpin from the Salt Marsh Plant Corydalis heterocarpa in LPS-Induced RAW 264.7 Macrophage Cells
title_fullStr Anti-Inflammatory Activity of Heterocarpin from the Salt Marsh Plant Corydalis heterocarpa in LPS-Induced RAW 264.7 Macrophage Cells
title_full_unstemmed Anti-Inflammatory Activity of Heterocarpin from the Salt Marsh Plant Corydalis heterocarpa in LPS-Induced RAW 264.7 Macrophage Cells
title_short Anti-Inflammatory Activity of Heterocarpin from the Salt Marsh Plant Corydalis heterocarpa in LPS-Induced RAW 264.7 Macrophage Cells
title_sort anti-inflammatory activity of heterocarpin from the salt marsh plant corydalis heterocarpa in lps-induced raw 264.7 macrophage cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332082/
https://www.ncbi.nlm.nih.gov/pubmed/26266403
http://dx.doi.org/10.3390/molecules200814474
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