A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm

The preparation of triazamacrocyclic hydroxypyridinonate (HOPO-TACN) derivatives as potential chelators for metals in biomedical applications was reported. The synthesis is based on a convergent synthetic approach, in which the key intermediate di-tert-butyl-2,2′-(1,4,7-triazonane-1,4-diyl) diacetat...

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Detalles Bibliográficos
Autores principales: Gai, Yongkang, Hu, Zhongping, Rong, Zhao, Ma, Xiang, Xiang, Guangya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332087/
https://www.ncbi.nlm.nih.gov/pubmed/26512638
http://dx.doi.org/10.3390/molecules201019393
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author Gai, Yongkang
Hu, Zhongping
Rong, Zhao
Ma, Xiang
Xiang, Guangya
author_facet Gai, Yongkang
Hu, Zhongping
Rong, Zhao
Ma, Xiang
Xiang, Guangya
author_sort Gai, Yongkang
collection PubMed
description The preparation of triazamacrocyclic hydroxypyridinonate (HOPO-TACN) derivatives as potential chelators for metals in biomedical applications was reported. The synthesis is based on a convergent synthetic approach, in which the key intermediate di-tert-butyl-2,2′-(1,4,7-triazonane-1,4-diyl) diacetate was coupled with a hydroxypyridinonate pendant arm. The method is suitable for rapid syntheses of metal chelator HOPO-TACNs of biomedical interest.
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spelling pubmed-63320872019-01-24 A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm Gai, Yongkang Hu, Zhongping Rong, Zhao Ma, Xiang Xiang, Guangya Molecules Article The preparation of triazamacrocyclic hydroxypyridinonate (HOPO-TACN) derivatives as potential chelators for metals in biomedical applications was reported. The synthesis is based on a convergent synthetic approach, in which the key intermediate di-tert-butyl-2,2′-(1,4,7-triazonane-1,4-diyl) diacetate was coupled with a hydroxypyridinonate pendant arm. The method is suitable for rapid syntheses of metal chelator HOPO-TACNs of biomedical interest. MDPI 2015-10-23 /pmc/articles/PMC6332087/ /pubmed/26512638 http://dx.doi.org/10.3390/molecules201019393 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gai, Yongkang
Hu, Zhongping
Rong, Zhao
Ma, Xiang
Xiang, Guangya
A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm
title A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm
title_full A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm
title_fullStr A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm
title_full_unstemmed A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm
title_short A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm
title_sort practical route for the preparation of 1,4,7-triazacyclononanyl diacetates with a hydroxypyridinonate pendant arm
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332087/
https://www.ncbi.nlm.nih.gov/pubmed/26512638
http://dx.doi.org/10.3390/molecules201019393
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