DNA Aptamers in the Diagnosis and Treatment of Human Diseases

Aptamers have a promising role in the field of life science and have been extensively researched for application as analytical tools, therapeutic agents and as vehicles for targeted drug delivery. Compared with RNA aptamers, DNA aptamers have inherent advantages in stability and facility of generati...

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Detalles Bibliográficos
Autores principales: Zhu, Qinchang, Liu, Ge, Kai, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332121/
https://www.ncbi.nlm.nih.gov/pubmed/26610462
http://dx.doi.org/10.3390/molecules201219739
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author Zhu, Qinchang
Liu, Ge
Kai, Masaaki
author_facet Zhu, Qinchang
Liu, Ge
Kai, Masaaki
author_sort Zhu, Qinchang
collection PubMed
description Aptamers have a promising role in the field of life science and have been extensively researched for application as analytical tools, therapeutic agents and as vehicles for targeted drug delivery. Compared with RNA aptamers, DNA aptamers have inherent advantages in stability and facility of generation and synthesis. To better understand the specific potential of DNA aptamers, an overview of the progress in the generation and application of DNA aptamers in human disease diagnosis and therapy are presented in this review. Special attention is given to researches that are relatively close to practical application. DNA aptamers are expected to have great potential in the diagnosis and treatment of human diseases.
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spelling pubmed-63321212019-01-24 DNA Aptamers in the Diagnosis and Treatment of Human Diseases Zhu, Qinchang Liu, Ge Kai, Masaaki Molecules Review Aptamers have a promising role in the field of life science and have been extensively researched for application as analytical tools, therapeutic agents and as vehicles for targeted drug delivery. Compared with RNA aptamers, DNA aptamers have inherent advantages in stability and facility of generation and synthesis. To better understand the specific potential of DNA aptamers, an overview of the progress in the generation and application of DNA aptamers in human disease diagnosis and therapy are presented in this review. Special attention is given to researches that are relatively close to practical application. DNA aptamers are expected to have great potential in the diagnosis and treatment of human diseases. MDPI 2015-11-25 /pmc/articles/PMC6332121/ /pubmed/26610462 http://dx.doi.org/10.3390/molecules201219739 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhu, Qinchang
Liu, Ge
Kai, Masaaki
DNA Aptamers in the Diagnosis and Treatment of Human Diseases
title DNA Aptamers in the Diagnosis and Treatment of Human Diseases
title_full DNA Aptamers in the Diagnosis and Treatment of Human Diseases
title_fullStr DNA Aptamers in the Diagnosis and Treatment of Human Diseases
title_full_unstemmed DNA Aptamers in the Diagnosis and Treatment of Human Diseases
title_short DNA Aptamers in the Diagnosis and Treatment of Human Diseases
title_sort dna aptamers in the diagnosis and treatment of human diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332121/
https://www.ncbi.nlm.nih.gov/pubmed/26610462
http://dx.doi.org/10.3390/molecules201219739
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