Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives

This paper describes the biocatalytic synthesis of new Mannich bases containing various heterocyclic rings (thiazole, furane, thiophene, pyridine) by applying the lipase catalyzed trimolecular condensation of the corresponding heterocyclic aldehydes with acetone and primary aromatic amines, in mild...

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Autores principales: Leonte, Denisa, Bencze, László Csaba, Paizs, Csaba, Irimie, Florin Dan, Zaharia, Valentin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332133/
https://www.ncbi.nlm.nih.gov/pubmed/26154887
http://dx.doi.org/10.3390/molecules200712300
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author Leonte, Denisa
Bencze, László Csaba
Paizs, Csaba
Irimie, Florin Dan
Zaharia, Valentin
author_facet Leonte, Denisa
Bencze, László Csaba
Paizs, Csaba
Irimie, Florin Dan
Zaharia, Valentin
author_sort Leonte, Denisa
collection PubMed
description This paper describes the biocatalytic synthesis of new Mannich bases containing various heterocyclic rings (thiazole, furane, thiophene, pyridine) by applying the lipase catalyzed trimolecular condensation of the corresponding heterocyclic aldehydes with acetone and primary aromatic amines, in mild and eco-friendly reaction conditions. The obtained Mannich bases were acylated to their corresponding N-acetyl derivatives. All compounds were characterized by (1)H-NMR, (13)C-NMR and MS spectrometry.
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spelling pubmed-63321332019-01-24 Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives Leonte, Denisa Bencze, László Csaba Paizs, Csaba Irimie, Florin Dan Zaharia, Valentin Molecules Article This paper describes the biocatalytic synthesis of new Mannich bases containing various heterocyclic rings (thiazole, furane, thiophene, pyridine) by applying the lipase catalyzed trimolecular condensation of the corresponding heterocyclic aldehydes with acetone and primary aromatic amines, in mild and eco-friendly reaction conditions. The obtained Mannich bases were acylated to their corresponding N-acetyl derivatives. All compounds were characterized by (1)H-NMR, (13)C-NMR and MS spectrometry. MDPI 2015-07-06 /pmc/articles/PMC6332133/ /pubmed/26154887 http://dx.doi.org/10.3390/molecules200712300 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Leonte, Denisa
Bencze, László Csaba
Paizs, Csaba
Irimie, Florin Dan
Zaharia, Valentin
Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives
title Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives
title_full Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives
title_fullStr Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives
title_full_unstemmed Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives
title_short Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives
title_sort heterocycles 38. biocatalytic synthesis of new heterocyclic mannich bases and derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332133/
https://www.ncbi.nlm.nih.gov/pubmed/26154887
http://dx.doi.org/10.3390/molecules200712300
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