Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito

A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides—adonioside A (1) and adonioside B (6)—as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and...

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Autores principales: Jung, Jae-Woo, Baek, Nam-In, Hwang-Bo, Jeon, Lee, Seung-Su, Park, Ji-Hae, Seo, Kyeong-Hwa, Kwon, Jung-Hwa, Oh, Eun-Ji, Lee, Dae-Young, Chung, In-Sik, Bang, Myun-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332151/
https://www.ncbi.nlm.nih.gov/pubmed/26610451
http://dx.doi.org/10.3390/molecules201119722
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author Jung, Jae-Woo
Baek, Nam-In
Hwang-Bo, Jeon
Lee, Seung-Su
Park, Ji-Hae
Seo, Kyeong-Hwa
Kwon, Jung-Hwa
Oh, Eun-Ji
Lee, Dae-Young
Chung, In-Sik
Bang, Myun-Ho
author_facet Jung, Jae-Woo
Baek, Nam-In
Hwang-Bo, Jeon
Lee, Seung-Su
Park, Ji-Hae
Seo, Kyeong-Hwa
Kwon, Jung-Hwa
Oh, Eun-Ji
Lee, Dae-Young
Chung, In-Sik
Bang, Myun-Ho
author_sort Jung, Jae-Woo
collection PubMed
description A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides—adonioside A (1) and adonioside B (6)—as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and cymarin (5). Their structures were elucidated on the basis of NMR, MS, and IR spectroscopic analyses. Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3).
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spelling pubmed-63321512019-01-24 Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito Jung, Jae-Woo Baek, Nam-In Hwang-Bo, Jeon Lee, Seung-Su Park, Ji-Hae Seo, Kyeong-Hwa Kwon, Jung-Hwa Oh, Eun-Ji Lee, Dae-Young Chung, In-Sik Bang, Myun-Ho Molecules Communication A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides—adonioside A (1) and adonioside B (6)—as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and cymarin (5). Their structures were elucidated on the basis of NMR, MS, and IR spectroscopic analyses. Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3). MDPI 2015-11-23 /pmc/articles/PMC6332151/ /pubmed/26610451 http://dx.doi.org/10.3390/molecules201119722 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Jung, Jae-Woo
Baek, Nam-In
Hwang-Bo, Jeon
Lee, Seung-Su
Park, Ji-Hae
Seo, Kyeong-Hwa
Kwon, Jung-Hwa
Oh, Eun-Ji
Lee, Dae-Young
Chung, In-Sik
Bang, Myun-Ho
Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito
title Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito
title_full Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito
title_fullStr Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito
title_full_unstemmed Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito
title_short Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito
title_sort two new cyototoxic cardenolides from the whole plants of adonis multiflora nishikawa & koki ito
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332151/
https://www.ncbi.nlm.nih.gov/pubmed/26610451
http://dx.doi.org/10.3390/molecules201119722
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