Efficient Synthesis of β-Aryl-γ-lactams and Their Resolution with (S)-Naproxen: Preparation of (R)- and (S)-Baclofen

An efficient synthesis of enantiomerically-pure β-aryl-γ-lactams is described. The principal feature of this synthesis is the practical resolution of β-aryl-γ-lactams with (S)-Naproxen. The procedure is based on the Michael addition of nitromethane to benzylidenemalonates, which was easily obtained,...

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Detalles Bibliográficos
Autores principales: Montoya-Balbás, Iris J., Valentín-Guevara, Berenice, López-Mendoza, Estefanía, Linzaga-Elizalde, Irma, Ordoñez, Mario, Román-Bravo, Perla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332160/
https://www.ncbi.nlm.nih.gov/pubmed/26690390
http://dx.doi.org/10.3390/molecules201219830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332160/
https://www.ncbi.nlm.nih.gov/pubmed/26690390
http://dx.doi.org/10.3390/molecules201219830

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