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Current Research on Antiepileptic Compounds

Epilepsy affects about 1% of the world’s population. Due to the fact all antiepileptic drugs (AEDs) have some undesirable side effects and about 30% of epileptic patients are not seizure-free with the existing AEDs, there is still an urgent need for the development of more effective and safer AEDs....

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Detalles Bibliográficos
Autores principales: Wei, Cheng-Xi, Bian, Ming, Gong, Guo-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332177/
https://www.ncbi.nlm.nih.gov/pubmed/26610448
http://dx.doi.org/10.3390/molecules201119714
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author Wei, Cheng-Xi
Bian, Ming
Gong, Guo-Hua
author_facet Wei, Cheng-Xi
Bian, Ming
Gong, Guo-Hua
author_sort Wei, Cheng-Xi
collection PubMed
description Epilepsy affects about 1% of the world’s population. Due to the fact all antiepileptic drugs (AEDs) have some undesirable side effects and about 30% of epileptic patients are not seizure-free with the existing AEDs, there is still an urgent need for the development of more effective and safer AEDs. Based on our research work on antiepileptic compounds and other references in recent years, this review covers the reported work on antiepileptic compounds which are classified according to their structures. This review summarized 244 significant anticonvulsant compounds which are classified by functional groups according to the animal model data, although there are some limitations in the data. This review highlights the properties of new compounds endowed with promising antiepileptic properties, which may be proven to be more effective and selective, and possibly free of unwanted side effects. The reviewed compounds represent an interesting possibility to overcome refractory seizures and to reduce the percentage of patients with a poor response to drug therapy.
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spelling pubmed-63321772019-01-24 Current Research on Antiepileptic Compounds Wei, Cheng-Xi Bian, Ming Gong, Guo-Hua Molecules Review Epilepsy affects about 1% of the world’s population. Due to the fact all antiepileptic drugs (AEDs) have some undesirable side effects and about 30% of epileptic patients are not seizure-free with the existing AEDs, there is still an urgent need for the development of more effective and safer AEDs. Based on our research work on antiepileptic compounds and other references in recent years, this review covers the reported work on antiepileptic compounds which are classified according to their structures. This review summarized 244 significant anticonvulsant compounds which are classified by functional groups according to the animal model data, although there are some limitations in the data. This review highlights the properties of new compounds endowed with promising antiepileptic properties, which may be proven to be more effective and selective, and possibly free of unwanted side effects. The reviewed compounds represent an interesting possibility to overcome refractory seizures and to reduce the percentage of patients with a poor response to drug therapy. MDPI 2015-11-20 /pmc/articles/PMC6332177/ /pubmed/26610448 http://dx.doi.org/10.3390/molecules201119714 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wei, Cheng-Xi
Bian, Ming
Gong, Guo-Hua
Current Research on Antiepileptic Compounds
title Current Research on Antiepileptic Compounds
title_full Current Research on Antiepileptic Compounds
title_fullStr Current Research on Antiepileptic Compounds
title_full_unstemmed Current Research on Antiepileptic Compounds
title_short Current Research on Antiepileptic Compounds
title_sort current research on antiepileptic compounds
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332177/
https://www.ncbi.nlm.nih.gov/pubmed/26610448
http://dx.doi.org/10.3390/molecules201119714
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