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A GC-MS Based Metabonomics Study of Rheumatoid Arthritis and the Interventional Effects of the Simiaowan in Rats

Simiaowan (SMW) is a famous Chinese prescription widely used in clinical treatment of rheumatoid arthritis (RA). The aim of the present study is to determine novel biomarkers to increase the current understanding of RA mechanisms, as well as the underlying therapeutic mechanism of SMW, in RA-model r...

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Detalles Bibliográficos
Autores principales: Wang, Yuming, Guo, Xuejun, Xie, Jiabin, Hou, Zhiguo, Li, Yubo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332181/
https://www.ncbi.nlm.nih.gov/pubmed/26633333
http://dx.doi.org/10.3390/molecules201219776
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author Wang, Yuming
Guo, Xuejun
Xie, Jiabin
Hou, Zhiguo
Li, Yubo
author_facet Wang, Yuming
Guo, Xuejun
Xie, Jiabin
Hou, Zhiguo
Li, Yubo
author_sort Wang, Yuming
collection PubMed
description Simiaowan (SMW) is a famous Chinese prescription widely used in clinical treatment of rheumatoid arthritis (RA). The aim of the present study is to determine novel biomarkers to increase the current understanding of RA mechanisms, as well as the underlying therapeutic mechanism of SMW, in RA-model rats. Plasma extracts from control, RA model, and SMW-treated rats were analyzed by gas chromatography coupled with mass spectrometry (GC-MS). An orthogonal partial least-square discriminant analysis (OPLS-DA) model was created to detect metabolites that were expressed in significantly different amounts between the RA model and the control rats and investigate the therapeutic effect of SMW. Metabonomics may prove to be a valuable tool for determining the efficacy of complex traditional prescriptions.
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spelling pubmed-63321812019-01-24 A GC-MS Based Metabonomics Study of Rheumatoid Arthritis and the Interventional Effects of the Simiaowan in Rats Wang, Yuming Guo, Xuejun Xie, Jiabin Hou, Zhiguo Li, Yubo Molecules Article Simiaowan (SMW) is a famous Chinese prescription widely used in clinical treatment of rheumatoid arthritis (RA). The aim of the present study is to determine novel biomarkers to increase the current understanding of RA mechanisms, as well as the underlying therapeutic mechanism of SMW, in RA-model rats. Plasma extracts from control, RA model, and SMW-treated rats were analyzed by gas chromatography coupled with mass spectrometry (GC-MS). An orthogonal partial least-square discriminant analysis (OPLS-DA) model was created to detect metabolites that were expressed in significantly different amounts between the RA model and the control rats and investigate the therapeutic effect of SMW. Metabonomics may prove to be a valuable tool for determining the efficacy of complex traditional prescriptions. MDPI 2015-12-01 /pmc/articles/PMC6332181/ /pubmed/26633333 http://dx.doi.org/10.3390/molecules201219776 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Yuming
Guo, Xuejun
Xie, Jiabin
Hou, Zhiguo
Li, Yubo
A GC-MS Based Metabonomics Study of Rheumatoid Arthritis and the Interventional Effects of the Simiaowan in Rats
title A GC-MS Based Metabonomics Study of Rheumatoid Arthritis and the Interventional Effects of the Simiaowan in Rats
title_full A GC-MS Based Metabonomics Study of Rheumatoid Arthritis and the Interventional Effects of the Simiaowan in Rats
title_fullStr A GC-MS Based Metabonomics Study of Rheumatoid Arthritis and the Interventional Effects of the Simiaowan in Rats
title_full_unstemmed A GC-MS Based Metabonomics Study of Rheumatoid Arthritis and the Interventional Effects of the Simiaowan in Rats
title_short A GC-MS Based Metabonomics Study of Rheumatoid Arthritis and the Interventional Effects of the Simiaowan in Rats
title_sort gc-ms based metabonomics study of rheumatoid arthritis and the interventional effects of the simiaowan in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332181/
https://www.ncbi.nlm.nih.gov/pubmed/26633333
http://dx.doi.org/10.3390/molecules201219776
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