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Enantioselective Solvent-Free Synthesis of 3-Alkyl-3-hydroxy-2-oxoindoles Catalyzed by Binam-Prolinamides

BINAM-prolinamides are very efficient catalyst for the synthesis of non-protected and N-benzyl isatin derivatives by using an aldol reaction between ketones and isatins under solvent-free conditions. The results in terms of diastereo- and enantioselectivities are good, up to 99% de and 97% ee, and h...

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Detalles Bibliográficos
Autores principales:	Bañón-Caballero, Abraham, Flores-Ferrándiz, Jesús, Guillena, Gabriela, Nájera, Carmen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332192/ https://www.ncbi.nlm.nih.gov/pubmed/26193246 http://dx.doi.org/10.3390/molecules200712901

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