Synthesis and Physicochemical Characterization of the Process-Related Impurities of Olmesartan Medoxomil. Do 5-(Biphenyl-2-yl)-1-triphenylmethyltetrazole Intermediates in Sartan Syntheses Exist?

During the process development for multigram-scale synthesis of olmesartan medoxomil (OM), two principal regioisomeric process-related impurities were observed along with the final active pharmaceutical ingredient (API). The impurities were identified as N-1- and N-2-(5-methyl-2-oxo-1,3-dioxolen-4-y...

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Detalles Bibliográficos
Autores principales: Dams, Iwona, Ostaszewska, Anna, Puchalska, Maria, Chmiel, Justyna, Cmoch, Piotr, Bujak, Iwona, Białońska, Agata, Szczepek, Wojciech J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332230/
https://www.ncbi.nlm.nih.gov/pubmed/26633332
http://dx.doi.org/10.3390/molecules201219762

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