Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus

Two new flavonoids, bakuisoflavone (1) and bakuflavanone (2), together with 15 known compounds, were isolated from the fruits of Psoralea corylifolia, and their structures were characterized by spectroscopic data. The effects of the isolated compounds on methicillin-resistant Staphylococcus aureus w...

Descripción completa

Detalles Bibliográficos
Autores principales: Cui, Yanmei, Taniguchi, Shoko, Kuroda, Teruo, Hatano, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332258/
https://www.ncbi.nlm.nih.gov/pubmed/26184136
http://dx.doi.org/10.3390/molecules200712500
_version_ 1783387307807604736
author Cui, Yanmei
Taniguchi, Shoko
Kuroda, Teruo
Hatano, Tsutomu
author_facet Cui, Yanmei
Taniguchi, Shoko
Kuroda, Teruo
Hatano, Tsutomu
author_sort Cui, Yanmei
collection PubMed
description Two new flavonoids, bakuisoflavone (1) and bakuflavanone (2), together with 15 known compounds, were isolated from the fruits of Psoralea corylifolia, and their structures were characterized by spectroscopic data. The effects of the isolated compounds on methicillin-resistant Staphylococcus aureus were also examined. We found that two compounds, isobavachalcone (10) and bakuchiol (12), showed noticeable antibacterial effects on the MRSA strains examined. Quantitation of the major constituents, including anti-MRSA constituents, was then performed. The results showed individual contents of 1.26%–16.49% (w/w) among the examined compounds in the ethyl acetate extract from P. corylifolia fruits.
format Online
Article
Text
id pubmed-6332258
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-63322582019-01-24 Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus Cui, Yanmei Taniguchi, Shoko Kuroda, Teruo Hatano, Tsutomu Molecules Article Two new flavonoids, bakuisoflavone (1) and bakuflavanone (2), together with 15 known compounds, were isolated from the fruits of Psoralea corylifolia, and their structures were characterized by spectroscopic data. The effects of the isolated compounds on methicillin-resistant Staphylococcus aureus were also examined. We found that two compounds, isobavachalcone (10) and bakuchiol (12), showed noticeable antibacterial effects on the MRSA strains examined. Quantitation of the major constituents, including anti-MRSA constituents, was then performed. The results showed individual contents of 1.26%–16.49% (w/w) among the examined compounds in the ethyl acetate extract from P. corylifolia fruits. MDPI 2015-07-09 /pmc/articles/PMC6332258/ /pubmed/26184136 http://dx.doi.org/10.3390/molecules200712500 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cui, Yanmei
Taniguchi, Shoko
Kuroda, Teruo
Hatano, Tsutomu
Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus
title Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus
title_full Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus
title_fullStr Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus
title_full_unstemmed Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus
title_short Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus
title_sort constituents of psoralea corylifolia fruits and their effects on methicillin-resistant staphylococcus aureus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332258/
https://www.ncbi.nlm.nih.gov/pubmed/26184136
http://dx.doi.org/10.3390/molecules200712500
work_keys_str_mv AT cuiyanmei constituentsofpsoraleacorylifoliafruitsandtheireffectsonmethicillinresistantstaphylococcusaureus
AT taniguchishoko constituentsofpsoraleacorylifoliafruitsandtheireffectsonmethicillinresistantstaphylococcusaureus
AT kurodateruo constituentsofpsoraleacorylifoliafruitsandtheireffectsonmethicillinresistantstaphylococcusaureus
AT hatanotsutomu constituentsofpsoraleacorylifoliafruitsandtheireffectsonmethicillinresistantstaphylococcusaureus

Ejemplares similares