Cargando…
Synthesis and Fungicidal Activity of β-Carboline Alkaloids and Their Derivatives
A series of β-Carboline derivatives were designed, synthesized, and evaluated for their fungicidal activities in this study. Several derivatives electively exhibited fungicidal activities against some fungi. Especially, compound F5 exhibited higher fungicidal activity against Rhizoctonia solani(53.3...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332272/ https://www.ncbi.nlm.nih.gov/pubmed/26263966 http://dx.doi.org/10.3390/molecules200813941 |
_version_ | 1783387311143124992 |
---|---|
author | Li, Zhibin Chen, Shaohua Zhu, Shaowen Luo, Jianjun Zhang, Yaomou Weng, Qunfang |
author_facet | Li, Zhibin Chen, Shaohua Zhu, Shaowen Luo, Jianjun Zhang, Yaomou Weng, Qunfang |
author_sort | Li, Zhibin |
collection | PubMed |
description | A series of β-Carboline derivatives were designed, synthesized, and evaluated for their fungicidal activities in this study. Several derivatives electively exhibited fungicidal activities against some fungi. Especially, compound F5 exhibited higher fungicidal activity against Rhizoctonia solani(53.35%) than commercial antiviral agent validamycin (36.4%); compound F16 exhibited high fungicidal activity against Oospora citriaurantii ex Persoon(43.28%). Some of the alkaloids and their derivatives (compounds F4 and F25) exhibited broad-spectrum fungicidal activity. Specifically, compound F4 exhibited excellent high broad-spectrum fungicidal activity in vitro, and the curative and protection activities against P. litchi in vivo reached 92.59% and 59.26%, respectively. The new derivative, F4, with optimized physicochemical properties, obviously exhibited higher activities both in vitro and in vivo; therefore, F4 may be used as a new lead structure for the development of fungicidal drugs. |
format | Online Article Text |
id | pubmed-6332272 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63322722019-01-24 Synthesis and Fungicidal Activity of β-Carboline Alkaloids and Their Derivatives Li, Zhibin Chen, Shaohua Zhu, Shaowen Luo, Jianjun Zhang, Yaomou Weng, Qunfang Molecules Article A series of β-Carboline derivatives were designed, synthesized, and evaluated for their fungicidal activities in this study. Several derivatives electively exhibited fungicidal activities against some fungi. Especially, compound F5 exhibited higher fungicidal activity against Rhizoctonia solani(53.35%) than commercial antiviral agent validamycin (36.4%); compound F16 exhibited high fungicidal activity against Oospora citriaurantii ex Persoon(43.28%). Some of the alkaloids and their derivatives (compounds F4 and F25) exhibited broad-spectrum fungicidal activity. Specifically, compound F4 exhibited excellent high broad-spectrum fungicidal activity in vitro, and the curative and protection activities against P. litchi in vivo reached 92.59% and 59.26%, respectively. The new derivative, F4, with optimized physicochemical properties, obviously exhibited higher activities both in vitro and in vivo; therefore, F4 may be used as a new lead structure for the development of fungicidal drugs. MDPI 2015-07-31 /pmc/articles/PMC6332272/ /pubmed/26263966 http://dx.doi.org/10.3390/molecules200813941 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li, Zhibin Chen, Shaohua Zhu, Shaowen Luo, Jianjun Zhang, Yaomou Weng, Qunfang Synthesis and Fungicidal Activity of β-Carboline Alkaloids and Their Derivatives |
title | Synthesis and Fungicidal Activity of β-Carboline Alkaloids and Their Derivatives |
title_full | Synthesis and Fungicidal Activity of β-Carboline Alkaloids and Their Derivatives |
title_fullStr | Synthesis and Fungicidal Activity of β-Carboline Alkaloids and Their Derivatives |
title_full_unstemmed | Synthesis and Fungicidal Activity of β-Carboline Alkaloids and Their Derivatives |
title_short | Synthesis and Fungicidal Activity of β-Carboline Alkaloids and Their Derivatives |
title_sort | synthesis and fungicidal activity of β-carboline alkaloids and their derivatives |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332272/ https://www.ncbi.nlm.nih.gov/pubmed/26263966 http://dx.doi.org/10.3390/molecules200813941 |
work_keys_str_mv | AT lizhibin synthesisandfungicidalactivityofbcarbolinealkaloidsandtheirderivatives AT chenshaohua synthesisandfungicidalactivityofbcarbolinealkaloidsandtheirderivatives AT zhushaowen synthesisandfungicidalactivityofbcarbolinealkaloidsandtheirderivatives AT luojianjun synthesisandfungicidalactivityofbcarbolinealkaloidsandtheirderivatives AT zhangyaomou synthesisandfungicidalactivityofbcarbolinealkaloidsandtheirderivatives AT wengqunfang synthesisandfungicidalactivityofbcarbolinealkaloidsandtheirderivatives |