Cargando…

In Silico Identification and in Vitro Activity of Novel Natural Inhibitors of Trypanosoma brucei Glyceraldehyde-3-phosphate-dehydrogenase †

As part of our ongoing efforts to identify natural products with activity against pathogens causing neglected tropical diseases, we are currently performing an extensive screening of natural product (NP) databases against a multitude of protozoan parasite proteins. Within this project, we screened a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Herrmann, Fabian C., Lenz, Mairin, Jose, Joachim, Kaiser, Marcel, Brun, Reto, Schmidt, Thomas J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332274/ https://www.ncbi.nlm.nih.gov/pubmed/26404225 http://dx.doi.org/10.3390/molecules200916154

Ejemplares similares

Glyceraldehyde 3-Phosphate Dehydrogenase-Telomere Association Correlates with Redox Status in Trypanosoma cruzi
por: Pariona-Llanos, Ricardo, et al.
Publicado: (2015)

Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense
por: Nnadi, Charles Okeke, et al.
Publicado: (2017)

In Silico and In Vitro Search for Dual Inhibitors of the Trypanosoma brucei and Leishmania major Pteridine Reductase 1 and Dihydrofolate Reductase
por: Possart, Katharina, et al.
Publicado: (2023)

THE HISTOCHEMICAL DEMONSTRATION OF GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE ACTIVITY
por: Himmelhoch, S. Ralph, et al.
Publicado: (1961)

THE INHIBITION OF d-GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE BY SPECIFIC ANTISERUM
por: Krebs, Edwin G., et al.
Publicado: (1948)

Testis-specific glyceraldehyde-3-phosphate dehydrogenase: origin and evolution
por: Kuravsky, Mikhail L, et al.
Publicado: (2011)

Functional consequences of piceatannol binding to glyceraldehyde-3-phosphate dehydrogenase
por: Gerszon, Joanna, et al.
Publicado: (2018)

Glyceraldehyde-3-phosphate Dehydrogenase Is a Multifaceted Therapeutic Target
por: Lazarev, Vladimir F., et al.
Publicado: (2020)

Role of Glyceraldehyde 3-Phosphate Dehydrogenase in the Development and Progression of Diabetic Retinopathy
por: Kanwar, Mamta, et al.
Publicado: (2009)

A cryoprotectant induces conformational change in glyceraldehyde-3-phosphate dehydrogenase
por: Kim, Yong Ju
Publicado: (2018)

Sperm glyceraldehyde 3-phosphate dehydrogenase gene expression in asthenozoospermic spermatozoa
por: Paoli, Donatella, et al.
Publicado: (2017)

Cytosolic Glyceraldehyde-3-Phosphate Dehydrogenase Is Phosphorylated during Seed Development
por: Piattoni, Claudia V., et al.
Publicado: (2017)

Aberrant Expression of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) in Warthin Tumors
por: Mandic, Robert, et al.
Publicado: (2020)

Bottlenecks and the Maintenance of Minor Genotypes during the Life Cycle of Trypanosoma brucei
por: Oberle, Michael, et al.
Publicado: (2010)

TKTL1 Knockdown Impairs Hypoxia-Induced Glucose-6-phosphate Dehydrogenase and Glyceraldehyde-3-phosphate Dehydrogenase Overexpression
por: Baptista, Inês, et al.
Publicado: (2022)

Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream Trypanosoma brucei
por: Ortíz, Cecilia, et al.
Publicado: (2021)

A mutation in glyceraldehyde 3-phosphate dehydrogenase alters endocytosis in CHO cells
Publicado: (1995)

Glyceraldehyde-3-Phosphate Dehydrogenase Acts as a Mitochondrial Trans-S-Nitrosylase in the Heart
por: Kohr, Mark J., et al.
Publicado: (2014)

The Plastidial Glyceraldehyde-3-Phosphate Dehydrogenase Is Critical for Abiotic Stress Response in Wheat
por: Li, Xixi, et al.
Publicado: (2019)

Interactome of Glyceraldehyde-3-Phosphate Dehydrogenase Points to the Existence of Metabolons in Paracoccidioides lutzii
por: e Silva, Kleber Santiago Freitas, et al.
Publicado: (2019)

Antimicrobial silver targets glyceraldehyde-3-phosphate dehydrogenase in glycolysis of E. coli
por: Wang, Haibo, et al.
Publicado: (2019)

Biosynthesis of the fungal glyceraldehyde-3-phosphate dehydrogenase inhibitor heptelidic acid and mechanism of self-resistance
por: Yan, Yan, et al.
Publicado: (2020)

Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol
por: Graf, Fabrice E., et al.
Publicado: (2013)

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library
por: Woodland, Andrew, et al.
Publicado: (2015)

A role for glyceraldehyde-3-phosphate dehydrogenase in the development of thermotolerance in Xenopus laevis embryos
Publicado: (1988)

The Glyceraldehyde-3-Phosphate Dehydrogenase and the Small GTPase Rab 2 Are Crucial for Brucella Replication
por: Fugier, Emilie, et al.
Publicado: (2009)

Glyceraldehyde-3-Phosphate Dehydrogenase: A Promising Target for Molecular Therapy in Hepatocellular Carcinoma
por: Ganapathy-Kanniappan, Shanmugasundaram, et al.
Publicado: (2012)

Pattern Recognition Techniques Applied to the Study of Leishmanial Glyceraldehyde-3-Phosphate Dehydrogenase Inhibition
por: Lozano, Norka B. H., et al.
Publicado: (2014)

Glyceraldehyde-3-Phosphate Dehydrogenase of Babesia microti Is a Plasminogen- and Actin-Binding Protein
por: Liu, Xiangye, et al.
Publicado: (2019)

Tyr‐Asp inhibition of glyceraldehyde 3‐phosphate dehydrogenase affects plant redox metabolism
por: Moreno, Juan C, et al.
Publicado: (2021)

Thermal stability and structure of glyceraldehyde-3-phosphate dehydrogenase from the coral Acropora millepora
por: Perez, Astrid M., et al.
Publicado: (2021)

Sesquiterpene Lactones with Dual Inhibitory Activity against the Trypanosoma brucei Pteridine Reductase 1 and Dihydrofolate Reductase
por: Possart, Katharina, et al.
Publicado: (2021)

The Multiple Localized Glyceraldehyde-3-Phosphate Dehydrogenase Contributes to the Attenuation of the Francisella tularensis dsbA Deletion Mutant
por: Pavkova, Ivona, et al.
Publicado: (2017)

Survival of Trypanosoma brucei in the Tsetse Fly Is Enhanced by the Expression of Specific Forms of Procyclin
por: Ruepp, Stefan, et al.
Publicado: (1997)

Posttranscriptional regulation of angiotensin II type 1 receptor expression by glyceraldehyde 3-phosphate dehydrogenase
por: Backlund, Michael, et al.
Publicado: (2009)

Glyceraldehyde-3-Phosphate Dehydrogenase Interacts with Proapoptotic Kinase Mst1 to Promote Cardiomyocyte Apoptosis
por: You, Bei, et al.
Publicado: (2013)

Identification of Glyceraldehyde 3-Phosphate Dehydrogenase Sequence and Expression Profiles in Tree Shrew (Tupaia belangeri)
por: Zheng, Yu, et al.
Publicado: (2014)

Glyceraldehyde 3-phosphate dehydrogenase negatively regulates human immunodeficiency virus type 1 infection
por: Kishimoto, Naoki, et al.
Publicado: (2012)

Characterization and possible function of glyceraldehyde-3-phosphate dehydrogenase-spermatogenic protein GAPDHS in mammalian sperm
por: Margaryan, Hasmik, et al.
Publicado: (2015)

Mycobacterium tuberculosis Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Functions as a Receptor for Human Lactoferrin
por: Malhotra, Himanshu, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ej7ibrjobr5mgnni7c30ur05s9