Quantitative (1)H-NMR Method for the Determination of Tadalafil in Bulk Drugs and its Tablets

A simple, rapid, accurate, and selective quantitative nuclear magnetic resonance method for the determination of tadalafil in bulk drugs and its tablets was established and evaluated. Spectra were obtained in dimethylsulfoxide-d(6) using 2,4-dinitrotoluene as the internal standard. In this study, th...

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Detalles Bibliográficos
Autores principales: Yang, Qingyun, Qiu, Hui, Guo, Wei, Wang, Dongmei, Zhou, Xingning, Xue, Dan, Zhang, Jinlan, Wu, Song, Wang, Yinghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332277/
https://www.ncbi.nlm.nih.gov/pubmed/26147583
http://dx.doi.org/10.3390/molecules200712114
Descripción
Sumario:A simple, rapid, accurate, and selective quantitative nuclear magnetic resonance method for the determination of tadalafil in bulk drugs and its tablets was established and evaluated. Spectra were obtained in dimethylsulfoxide-d(6) using 2,4-dinitrotoluene as the internal standard. In this study, the method’s linearity, range, limit of quantification, stability, precision, and accuracy were validated. The results were consistent with those obtained from high-performance liquid chromatography analysis. Thus, the proposed method is a useful and practical tool for the determination of tadalafil in bulk drugs and its tablets.

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