Quantitative (1)H-NMR Method for the Determination of Tadalafil in Bulk Drugs and its Tablets

A simple, rapid, accurate, and selective quantitative nuclear magnetic resonance method for the determination of tadalafil in bulk drugs and its tablets was established and evaluated. Spectra were obtained in dimethylsulfoxide-d(6) using 2,4-dinitrotoluene as the internal standard. In this study, th...

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Autores principales: Yang, Qingyun, Qiu, Hui, Guo, Wei, Wang, Dongmei, Zhou, Xingning, Xue, Dan, Zhang, Jinlan, Wu, Song, Wang, Yinghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332277/
https://www.ncbi.nlm.nih.gov/pubmed/26147583
http://dx.doi.org/10.3390/molecules200712114
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author Yang, Qingyun
Qiu, Hui
Guo, Wei
Wang, Dongmei
Zhou, Xingning
Xue, Dan
Zhang, Jinlan
Wu, Song
Wang, Yinghong
author_facet Yang, Qingyun
Qiu, Hui
Guo, Wei
Wang, Dongmei
Zhou, Xingning
Xue, Dan
Zhang, Jinlan
Wu, Song
Wang, Yinghong
author_sort Yang, Qingyun
collection PubMed
description A simple, rapid, accurate, and selective quantitative nuclear magnetic resonance method for the determination of tadalafil in bulk drugs and its tablets was established and evaluated. Spectra were obtained in dimethylsulfoxide-d(6) using 2,4-dinitrotoluene as the internal standard. In this study, the method’s linearity, range, limit of quantification, stability, precision, and accuracy were validated. The results were consistent with those obtained from high-performance liquid chromatography analysis. Thus, the proposed method is a useful and practical tool for the determination of tadalafil in bulk drugs and its tablets.
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spelling pubmed-63322772019-01-24 Quantitative (1)H-NMR Method for the Determination of Tadalafil in Bulk Drugs and its Tablets Yang, Qingyun Qiu, Hui Guo, Wei Wang, Dongmei Zhou, Xingning Xue, Dan Zhang, Jinlan Wu, Song Wang, Yinghong Molecules Article A simple, rapid, accurate, and selective quantitative nuclear magnetic resonance method for the determination of tadalafil in bulk drugs and its tablets was established and evaluated. Spectra were obtained in dimethylsulfoxide-d(6) using 2,4-dinitrotoluene as the internal standard. In this study, the method’s linearity, range, limit of quantification, stability, precision, and accuracy were validated. The results were consistent with those obtained from high-performance liquid chromatography analysis. Thus, the proposed method is a useful and practical tool for the determination of tadalafil in bulk drugs and its tablets. MDPI 2015-07-02 /pmc/articles/PMC6332277/ /pubmed/26147583 http://dx.doi.org/10.3390/molecules200712114 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Qingyun
Qiu, Hui
Guo, Wei
Wang, Dongmei
Zhou, Xingning
Xue, Dan
Zhang, Jinlan
Wu, Song
Wang, Yinghong
Quantitative (1)H-NMR Method for the Determination of Tadalafil in Bulk Drugs and its Tablets
title Quantitative (1)H-NMR Method for the Determination of Tadalafil in Bulk Drugs and its Tablets
title_full Quantitative (1)H-NMR Method for the Determination of Tadalafil in Bulk Drugs and its Tablets
title_fullStr Quantitative (1)H-NMR Method for the Determination of Tadalafil in Bulk Drugs and its Tablets
title_full_unstemmed Quantitative (1)H-NMR Method for the Determination of Tadalafil in Bulk Drugs and its Tablets
title_short Quantitative (1)H-NMR Method for the Determination of Tadalafil in Bulk Drugs and its Tablets
title_sort quantitative (1)h-nmr method for the determination of tadalafil in bulk drugs and its tablets
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332277/
https://www.ncbi.nlm.nih.gov/pubmed/26147583
http://dx.doi.org/10.3390/molecules200712114
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