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Separation and Identification of Four New Compounds with Antibacterial Activity from Portulaca oleracea L.

The Portulaca oleracea L. (P. oleracea) has been used to treat bacillary dysentery for thousands of years in China. Pharmacology studies on P. oleracea have also showed its significant antibacterial effects on the enteropathogenic bacteria, which might reveal the treatment of P. oleracea in cases of...

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Autores principales: Lei, Xia, Li, Jianmin, Liu, Bin, Zhang, Ning, Liu, Haiyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332283/
https://www.ncbi.nlm.nih.gov/pubmed/26378504
http://dx.doi.org/10.3390/molecules200916375
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author Lei, Xia
Li, Jianmin
Liu, Bin
Zhang, Ning
Liu, Haiyang
author_facet Lei, Xia
Li, Jianmin
Liu, Bin
Zhang, Ning
Liu, Haiyang
author_sort Lei, Xia
collection PubMed
description The Portulaca oleracea L. (P. oleracea) has been used to treat bacillary dysentery for thousands of years in China. Pharmacology studies on P. oleracea have also showed its significant antibacterial effects on the enteropathogenic bacteria, which might reveal the treatment of P. oleracea in cases of bacillary dysentery to some extent. To date, however, the therapeutic basis of P. oleracea treating on bacillary dysentery remains unknown. We determined the antibacterial effective fraction of P. oleracea in a previous study. The current study, which is based on our previous study, was first designed to isolate, identify and screen antibacterial active constituents from P. oleracea. As a result, four new compounds (1–4), portulacerebroside B (1), portulacerebroside C (2), portulacerebroside D (3) and portulaceramide A (4) along with five known compounds (5–9) were isolated, and structures were established by their physico-chemical constants and spectroscopic analysis. The antibacterial activities against common enteropathogenic bacteria were evaluated for all compounds and the new compounds 1–4 showed significant antibacterial effect on enteropathogenic bacteria in vitro, which might contribute to revealing the treatment of P. oleracea in cases of bacillary dysentery.
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spelling pubmed-63322832019-01-24 Separation and Identification of Four New Compounds with Antibacterial Activity from Portulaca oleracea L. Lei, Xia Li, Jianmin Liu, Bin Zhang, Ning Liu, Haiyang Molecules Article The Portulaca oleracea L. (P. oleracea) has been used to treat bacillary dysentery for thousands of years in China. Pharmacology studies on P. oleracea have also showed its significant antibacterial effects on the enteropathogenic bacteria, which might reveal the treatment of P. oleracea in cases of bacillary dysentery to some extent. To date, however, the therapeutic basis of P. oleracea treating on bacillary dysentery remains unknown. We determined the antibacterial effective fraction of P. oleracea in a previous study. The current study, which is based on our previous study, was first designed to isolate, identify and screen antibacterial active constituents from P. oleracea. As a result, four new compounds (1–4), portulacerebroside B (1), portulacerebroside C (2), portulacerebroside D (3) and portulaceramide A (4) along with five known compounds (5–9) were isolated, and structures were established by their physico-chemical constants and spectroscopic analysis. The antibacterial activities against common enteropathogenic bacteria were evaluated for all compounds and the new compounds 1–4 showed significant antibacterial effect on enteropathogenic bacteria in vitro, which might contribute to revealing the treatment of P. oleracea in cases of bacillary dysentery. MDPI 2015-09-10 /pmc/articles/PMC6332283/ /pubmed/26378504 http://dx.doi.org/10.3390/molecules200916375 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lei, Xia
Li, Jianmin
Liu, Bin
Zhang, Ning
Liu, Haiyang
Separation and Identification of Four New Compounds with Antibacterial Activity from Portulaca oleracea L.
title Separation and Identification of Four New Compounds with Antibacterial Activity from Portulaca oleracea L.
title_full Separation and Identification of Four New Compounds with Antibacterial Activity from Portulaca oleracea L.
title_fullStr Separation and Identification of Four New Compounds with Antibacterial Activity from Portulaca oleracea L.
title_full_unstemmed Separation and Identification of Four New Compounds with Antibacterial Activity from Portulaca oleracea L.
title_short Separation and Identification of Four New Compounds with Antibacterial Activity from Portulaca oleracea L.
title_sort separation and identification of four new compounds with antibacterial activity from portulaca oleracea l.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332283/
https://www.ncbi.nlm.nih.gov/pubmed/26378504
http://dx.doi.org/10.3390/molecules200916375
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