Lead Optimization of 2-Cyclohexyl-N-[(Z)-(3-methoxyphenyl/3-hydroxyphenyl) methylidene]hydrazinecarbothioamides for Targeting the HER-2 Overexpressed Breast Cancer Cell Line SKBr-3

Lead derivatives of 2-cyclohexyl-N-[(Z)-(3-methoxyphenyl/3-hydroxyphenyl) methylidene]hydrazinecarbothioamides 1–18 were synthesized, characterized and evaluated in vitro against HER-2 overexpressed breast cancer cell line SKBr-3. All the compounds showed activity against HER-2 overexpressed SKBr-3...

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Detalles Bibliográficos
Autores principales: Bhat, Mashooq A., Al-Dhfyan, Abdullah, Naglah, Ahmed M., Ali Khan, Azmat, Al-Omar, Mohamed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332285/
https://www.ncbi.nlm.nih.gov/pubmed/26457700
http://dx.doi.org/10.3390/molecules201018246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332285/
https://www.ncbi.nlm.nih.gov/pubmed/26457700
http://dx.doi.org/10.3390/molecules201018246

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