Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing

Significant process intensification of the amination reactions of aryl halides and esters has been demonstrated using continuous flow processing. Using this technology traditionally difficult amination reactions have been performed safely at elevated temperatures. These reactions were successfully c...

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Detalles Bibliográficos
Autores principales: Kohl, Thomas M., Hornung, Christian H., Tsanaktsidis, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332322/
https://www.ncbi.nlm.nih.gov/pubmed/26426000
http://dx.doi.org/10.3390/molecules201017860
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author Kohl, Thomas M.
Hornung, Christian H.
Tsanaktsidis, John
author_facet Kohl, Thomas M.
Hornung, Christian H.
Tsanaktsidis, John
author_sort Kohl, Thomas M.
collection PubMed
description Significant process intensification of the amination reactions of aryl halides and esters has been demonstrated using continuous flow processing. Using this technology traditionally difficult amination reactions have been performed safely at elevated temperatures. These reactions were successfully conducted on laboratory scale coil reactor modules with 1 mm internal diameter (ID) and on a preparatory scale tubular reactor with 6 mm ID containing static mixers.
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spelling pubmed-63323222019-01-24 Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing Kohl, Thomas M. Hornung, Christian H. Tsanaktsidis, John Molecules Article Significant process intensification of the amination reactions of aryl halides and esters has been demonstrated using continuous flow processing. Using this technology traditionally difficult amination reactions have been performed safely at elevated temperatures. These reactions were successfully conducted on laboratory scale coil reactor modules with 1 mm internal diameter (ID) and on a preparatory scale tubular reactor with 6 mm ID containing static mixers. MDPI 2015-09-25 /pmc/articles/PMC6332322/ /pubmed/26426000 http://dx.doi.org/10.3390/molecules201017860 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kohl, Thomas M.
Hornung, Christian H.
Tsanaktsidis, John
Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing
title Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing
title_full Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing
title_fullStr Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing
title_full_unstemmed Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing
title_short Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing
title_sort amination of aryl halides and esters using intensified continuous flow processing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332322/
https://www.ncbi.nlm.nih.gov/pubmed/26426000
http://dx.doi.org/10.3390/molecules201017860
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