Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza)

Four new cyclohexylideneacetonitrile derivatives 1–4, named menisdaurins B–E, as well as three known cyclohexylideneacetonitrile derivatives—menisdaurin (5), coclauril (6), and menisdaurilide (7)—were isolated from the hypocotyl of a mangrove (Bruguiera gymnorrhiza). The structures of the isolates w...

Descripción completa

Detalles Bibliográficos
Autores principales: Yi, Xiang-Xi, Deng, Jia-Gang, Gao, Cheng-Hai, Hou, Xiao-Tao, Li, Fei, Wang, Zhi-Ping, Hao, Er-Wei, Xie, Yan, Du, Zheng-Cai, Huang, Hui-Xue, Huang, Ri-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332330/
https://www.ncbi.nlm.nih.gov/pubmed/26274945
http://dx.doi.org/10.3390/molecules200814565
Descripción
Sumario:Four new cyclohexylideneacetonitrile derivatives 1–4, named menisdaurins B–E, as well as three known cyclohexylideneacetonitrile derivatives—menisdaurin (5), coclauril (6), and menisdaurilide (7)—were isolated from the hypocotyl of a mangrove (Bruguiera gymnorrhiza). The structures of the isolates were elucidated on the basis of extensive spectroscopic analysis. Compounds 1–7 showed anti-Hepatitis B virus (HBV) activities, with EC(50) values ranging from 5.1 ± 0.2 μg/mL to 87.7 ± 5.8 μg/mL.

Ejemplares similares