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Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza)
Four new cyclohexylideneacetonitrile derivatives 1–4, named menisdaurins B–E, as well as three known cyclohexylideneacetonitrile derivatives—menisdaurin (5), coclauril (6), and menisdaurilide (7)—were isolated from the hypocotyl of a mangrove (Bruguiera gymnorrhiza). The structures of the isolates w...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332330/ https://www.ncbi.nlm.nih.gov/pubmed/26274945 http://dx.doi.org/10.3390/molecules200814565 |
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| author | Yi, Xiang-Xi Deng, Jia-Gang Gao, Cheng-Hai Hou, Xiao-Tao Li, Fei Wang, Zhi-Ping Hao, Er-Wei Xie, Yan Du, Zheng-Cai Huang, Hui-Xue Huang, Ri-Ming |
| author_facet | Yi, Xiang-Xi Deng, Jia-Gang Gao, Cheng-Hai Hou, Xiao-Tao Li, Fei Wang, Zhi-Ping Hao, Er-Wei Xie, Yan Du, Zheng-Cai Huang, Hui-Xue Huang, Ri-Ming |
| author_sort | Yi, Xiang-Xi |
| collection | PubMed |
| description | Four new cyclohexylideneacetonitrile derivatives 1–4, named menisdaurins B–E, as well as three known cyclohexylideneacetonitrile derivatives—menisdaurin (5), coclauril (6), and menisdaurilide (7)—were isolated from the hypocotyl of a mangrove (Bruguiera gymnorrhiza). The structures of the isolates were elucidated on the basis of extensive spectroscopic analysis. Compounds 1–7 showed anti-Hepatitis B virus (HBV) activities, with EC(50) values ranging from 5.1 ± 0.2 μg/mL to 87.7 ± 5.8 μg/mL. |
| format | Online Article Text |
| id | pubmed-6332330 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-63323302019-01-24 Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza) Yi, Xiang-Xi Deng, Jia-Gang Gao, Cheng-Hai Hou, Xiao-Tao Li, Fei Wang, Zhi-Ping Hao, Er-Wei Xie, Yan Du, Zheng-Cai Huang, Hui-Xue Huang, Ri-Ming Molecules Article Four new cyclohexylideneacetonitrile derivatives 1–4, named menisdaurins B–E, as well as three known cyclohexylideneacetonitrile derivatives—menisdaurin (5), coclauril (6), and menisdaurilide (7)—were isolated from the hypocotyl of a mangrove (Bruguiera gymnorrhiza). The structures of the isolates were elucidated on the basis of extensive spectroscopic analysis. Compounds 1–7 showed anti-Hepatitis B virus (HBV) activities, with EC(50) values ranging from 5.1 ± 0.2 μg/mL to 87.7 ± 5.8 μg/mL. MDPI 2015-08-12 /pmc/articles/PMC6332330/ /pubmed/26274945 http://dx.doi.org/10.3390/molecules200814565 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Yi, Xiang-Xi Deng, Jia-Gang Gao, Cheng-Hai Hou, Xiao-Tao Li, Fei Wang, Zhi-Ping Hao, Er-Wei Xie, Yan Du, Zheng-Cai Huang, Hui-Xue Huang, Ri-Ming Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza) |
| title | Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza) |
| title_full | Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza) |
| title_fullStr | Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza) |
| title_full_unstemmed | Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza) |
| title_short | Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza) |
| title_sort | four new cyclohexylideneacetonitrile derivatives from the hypocotyl of mangrove (bruguiera gymnorrhiza) |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332330/ https://www.ncbi.nlm.nih.gov/pubmed/26274945 http://dx.doi.org/10.3390/molecules200814565 |
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